PMID: 2506903Sep 1, 1989Paper

Frequent detection of HIV- and IgG-specific IgM and IgA antibodies in HIV-positive cord-blood sera: fine analysis by western blot

AIDS
J SchüpbachZ Tomasik

Abstract

Cord-blood sera of 36 babies born to HIV-positive mothers in Switzerland were tested for immunoglobulin (Ig) M or IgA by HIV Western blot. IgM was found in 28, and IgA in 19 of unabsorbed sera. Preabsorption with immobilized protein A or G was used to remove IgG, which allowed differentiation between HIV-specific and IgG-specific IgM or IgA. Protein G proved superior and showed that 30% of 23 sera had HIV-specific IgM, while 48% had HIV-specific IgA. HIV-specific IgM and/or IgA was found in 13 out of 21 cases (62%); four out of 21 (19%) had both. HIV-specific IgM reacted most frequently with pol or env proteins, while HIV-specific IgA reacted more frequently with gag than pol; no IgA were directed against env proteins. IgG-specific IgM and IgA, mostly at gag bands, were present in 83 and 38%, respectively. Thus, a large percentage of children born to HIV-positive mothers have HIV-specific IgA and/or IgM which can be distinguished from IgG-specific IgA or IgM, which is also present in the majority of such children. Future studies will have to show whether these antibodies are of diagnostic relevance.

Citations

Jan 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M C ReM La Placa
Sep 28, 1996·Lancet·G Scarlatti
Mar 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·J Y Mok
Jun 13, 1992·BMJ : British Medical Journal·P PortincasaC Chezzi
Sep 20, 1993·Annals of the New York Academy of Sciences·D W ArchibaldJ P Johnson
May 29, 2008·Clinical and Experimental Immunology·C FarquharG John-Stewart
Jan 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kee Thai YeoArlene Dent
Feb 1, 1992·Immunological Investigations·N L MartinD W Wara

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