Frequent expression of bcl-2 protein in solitary fibrous tumors

Japanese Journal of Clinical Oncology
T HasegawaT Sano

Abstract

The distinction of solitary fibrous tumors from histologically similar neoplasms is often difficult because they rarely occur at a variety of extrapleural sites. CD34 immunoreactivity has recently been recognized to be an adjunct for the diagnosis of solitary fibrous tumors. However, it is now known that CD34 staining is not entirely specific for this entity. We evaluated 23 solitary fibrous tumors and 54 other spindle cell tumors often considered in the differential diagnosis for immunoreactivity using monoclonal antibodies directed against bcl-2 protein, which protects cells from apoptosis and CD34. The patients with solitary fibrous tumors comprised 11 men and 12 women, ranging in age from 35 to 85 years (mean, 57.6 years). Fourteen tumors arose in the pleura, four in the retroperitoneum, three in the superficial soft tissue and one each in the mediastinum and uterine cervix. Nineteen of 23 solitary fibrous tumors (83%), irrespective of tumor site, demonstrated diffuse cytoplasmic staining for bcl-2 protein. bcl-2 immunoreactivity was also observed in five of seven neurofibromas (71%), eight of 10 synovial sarcomas (80%) and one of three spindle cell lipomas (33%). CD34 immunoreactivity was present in all but one solitary fi...Continue Reading

References

Jul 1, 1991·American Journal of Clinical Pathology·S T TraweekH Battifora
Dec 1, 1991·Histopathology·J R Goodlad, C D Fletcher
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Aug 1, 1989·The American Journal of Surgical Pathology·D M EnglandM J McCarthy
Aug 1, 1994·The American Journal of Surgical Pathology·M van de RijnR V Rouse
Oct 1, 1994·The American Journal of Surgical Pathology·W H WestraJ Rosai
Nov 1, 1995·The American Journal of Surgical Pathology·S SusterC A Moran
Oct 1, 1993·The American Journal of Surgical Pathology·S W Weiss, B J Nickoloff
Jan 1, 1995·Histopathology·F Pezzella, K Gatter
Jan 1, 1994·Acta Neuropathologica·S NakasuJ Handa
Jan 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J P Eichelberger
Apr 1, 1993·The Journal of Pathology·Q L LuA M Hanby
Jan 1, 1996·Cancer Genetics and Cytogenetics·P Dal CinH Van den Berghe
Feb 1, 1996·Human Pathology·Q L LuE N Lalani
Dec 1, 1995·Pathology International·M FukunagaE Ishikawa
Sep 1, 1996·American Journal of Clinical Pathology·T HasegawaT Sano
Aug 1, 1996·Histopathology·M A DadaK C Gatter
Feb 1, 1997·The American Journal of Surgical Pathology·S Suster, C Fisher
Apr 1, 1997·The Journal of Pathology·M ChilosiG Viale

❮ Previous
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Citations

Feb 22, 2012·Skeletal Radiology·Josep Garcia-BennettPere Huguet
Jan 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Stéphane ZalinskiOlivier Soubrane
Oct 26, 2005·Current Treatment Options in Oncology·R Lor RandallKaren H Albritton
Jul 14, 2012·Journal of Gastrointestinal Cancer·Adeline AiméPierre Balladur
Jan 16, 2014·Indian Journal of Surgical Oncology·Rachel Maria Gomes, Dilip Kothari
Feb 5, 2004·Journal of the American College of Surgeons·Yoshihide NagasakoHidekazu Sano
Sep 23, 2003·Survey of Ophthalmology·Subramanian KrishnakumarNarsing A Rao
Nov 20, 2003·Urology·Diana WiessnerManfred P Wirth
Jun 22, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hsuan-Ying HuangWei-Jen Chen
Jun 10, 2000·Pathology International·Y AkiyamaM Koono
Jul 27, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Bruno CourrierRoger Küffer
Feb 22, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Walid Abu Arab
Jan 15, 2004·Pathology International·Hongquan ZhangMingxin Che
Jun 23, 2010·AJR. American Journal of Roentgenology·Oliver J WignallJoseph M Thomas
May 22, 2010·AJR. American Journal of Roentgenology·Ty K SubhawongLaura M Fayad
Aug 11, 2012·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Kazumi HashizumeHidehiro Kakizaki
Nov 6, 2012·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Cong WangToshitsugu Oka
Jan 9, 2014·BMC Women's Health·Andrzej NowakowskiWłodzimierz Baranowski
Feb 26, 2013·AJR. American Journal of Roentgenology·Jeffrey Forris Beecham ChickRachna Madan
Oct 3, 2014·Case Reports in Obstetrics and Gynecology·Youssef BenabdejlilMohamed Dehayni
Jun 12, 2002·Current Treatment Options in Oncology·M de Perrot
Jun 18, 2014·Skeletal Radiology·Kantang SatayasoontornDaniel Vanel
Apr 23, 2008·World Journal of Surgery·Chunlai LuDi Ge
Jul 5, 2011·Clinical Imaging·Andry Roussel HerijoelisonJean Noël Bruneton
Feb 4, 2011·Gynécologie, obstétrique & fertilité·C VaysseP Leguevaque
May 12, 2007·Pathology, Research and Practice·Pavol ZuborJan Danko
Apr 2, 2005·The Journal of Dermatology·Yuichi YoshidaJuichiro Nakayama
Aug 14, 2009·Gynecologic Oncology·Emma L SidebothamNadeem R Abu-Rustum
Mar 17, 2015·The Journal of Surgical Research·Severin SchmidSebastian Wiesemann
May 8, 2016·Radiologic Clinics of North America·Abhishek R KeraliyaNikhil H Ramaiya
Jun 5, 2003·Clinical Orthopaedics and Related Research·Toshihiro AkisueMasahiro Kurosaka
Dec 30, 2006·Journal of Lower Genital Tract Disease·Pratibha IyengarMahmoud A Khalifa
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Olaf James BiedrzyckiAsma Faruqi
Oct 20, 2007·Journal of Cutaneous Pathology·Gulsun ErdagMark R Wick
Feb 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kurosh RahimiRunjan Chetty
Apr 20, 2005·Journal of Pediatric Hematology/oncology·Karen H Albritton, R Lor Randall
Jun 5, 2001·Ophthalmic Plastic and Reconstructive Surgery·J W GigantelliJ S Kennerdell
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·M K KimY L Oh
Aug 14, 2012·Advances in Anatomic Pathology·Nelson G Ordóñez
Jul 5, 2011·Journal of Clinical Pathology·Matthew P WaltersAndrew L Folpe
Oct 23, 2015·Journal of Gastrointestinal Cancer·Marcelo A Beltrán
Jan 27, 2016·International Journal of Surgical Pathology·Khin ThwayCyril Fisher

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