Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma.

Human Pathology
Gabriela GualcoCarlos E Bacchi

Abstract

Burkitt lymphoma is a highly aggressive non-Hodgkin lymphoma with endemic, sporadic, and immunodeficiency-associated clinical variants composed of monomorphic medium-sized B cells with a high proliferation rate and a translocation involving the C-MYC locus. Classically, the immunophenotype of Burkitt lymphoma has been considered to be the germinal center type. In most reports, all cases of Burkitt lymphoma are reported to be multiple myeloma 1-negative. multiple myeloma 1 expression is seen in plasma cells and in a small fraction of B cells located in the light zone of germinal centers corresponding to the final step of intra-germinal center B-cell differentiation, and in activated T cells. Therefore, multiple myeloma 1 expression may denote the final step of intra-germinal center B-cell differentiation at the centrocyte stage, as well as the subsequent steps of B-cell maturation toward plasma cells. Unlike most normal germinal center B cells, in which the expression of multiple myeloma 1 and bcl-6 are mutually exclusive, the tumor cells in approximately 50% of multiple myeloma 1-positive DLBCL show coexpression of bcl-6, suggesting that the expression of these proteins may be deregulated. Twenty-five Burkitt lymphoma cases, in...Continue Reading

References

Nov 5, 1997·Nature Genetics·S IidaR Dalla-Favera
Jun 10, 1998·Cytokine & Growth Factor Reviews·H NguyenP M Pitha
Jul 17, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y NatkunamM van De Rijn
Mar 17, 2004·American Journal of Clinical Pathology·Michael FrostSherrie L Perkins
Jul 20, 2006·British Journal of Haematology·Sergio B CogliattiUNKNOWN Swiss Group for Clinical Cancer Research (SAKK)
Aug 10, 2006·Virchows Archiv : an International Journal of Pathology·Iguaracyra AraujoHarald Stein
Jan 2, 2007·Advances in Anatomic Pathology·Maurilio PonzoniClaudio Doglioni

❮ Previous
Next ❯

Citations

Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jason T YusteinChi V Dang
Oct 15, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gabriela GualcoCarlos E Bacchi
Apr 17, 2010·American Journal of Clinical Pathology·Stephanie D SchniederjanKaren P Mann
Jul 16, 2015·Genes, Chromosomes & Cancer·Rabea WagenerUNKNOWN "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe
Jan 13, 2017·The American Journal of Surgical Pathology·Akira SatouShigeo Nakamura
Feb 13, 2015·Chinese Medical Journal·Hui HuangWen-Ping Yang
Feb 26, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gabriela GualcoCarlos E Bacchi
Oct 17, 2014·The American Journal of Surgical Pathology·Akira SatouShigeo Nakamura
Jun 20, 2017·Histopathology·Marco PizziElena Sabattini
Nov 11, 2019·Pathology·Mario L Marques-PiubelliRoberto N Miranda
Nov 23, 2021·International Journal of Laboratory Hematology·Lanisha D FullerHeesun J Rogers

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.