PMID: 9171998Jun 1, 1997Paper

Frequent homozygous deletion of cyclin-dependent kinase inhibitor 2 (MTS1, p16) in superficial bladder cancer detected by fluorescence in situ hybridization

Genes, Chromosomes & Cancer
M BalázsF Waldman

Abstract

Deletion of all or part of chromosome 9 is a well-described genetic alteration in bladder tumors. It has been proposed that inactivation of a tumor-suppressor gene on chromosome 9 is an important event in tumor development. Recent reports have supported cyclin-dependent kinase inhibitor 2 (CDKN2, also known as MTS1, INK4, p16) at 9p21 as a candidate tumor-suppressor gene in solid tumors. However, the prevalence of CDKN2 mutations in primary bladder tumors has been controversial. Therefore, we applied gene-specific probes for CDKN2 and the interferon alpha gene (IFNA), also located at 9p21, to characterize further the genomic deletions at this locus in bladder cancer. Seventeen superficial (pTa or pT1) bladder tumor specimens were examined for gene deletion by fluorescence in situ hybridization. Dual-labeling hybridization with a repetitive pericentromeric probe for chromosome 9 and a gene-specific probe for CDKN2 was performed to characterize the gene copy number in relation to the chromosome 9 copy number on a cell-by-cell basis. Homozygous deletion for CDKN2 without homozygous IFNA deletion was found in 5 of 17 tumors tested. Both genes were deleted in one additional case, and one tumor showed deletion of IFNA without deletio...Continue Reading

Citations

May 9, 2002·Cancer Genetics and Cytogenetics·Manabu TsukamotoKatsusuke Naito
Mar 21, 2003·Cancer Genetics and Cytogenetics·Helen Therese Moriarty, Lucy Robyn Webster
Jun 18, 2003·Cancer Genetics and Cytogenetics·Laura CasorzoMauro Risio
Mar 7, 1998·Genes & Development·T R YeagerC A Reznikoff
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Shigeru SakanoPer Larsson
Sep 19, 2000·Genes, Chromosomes & Cancer·I Fadl-ElmulaS Heim
Mar 29, 2002·Genes, Chromosomes & Cancer·Sarah V WilliamsMargaret A Knowles
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·E BaudY J Bignon
Apr 7, 2009·Cancer·Susana FerraOscar Lin

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