Frequent Implication of Multistress-Tolerant Campylobacter jejuni in Human Infections

Emerging Infectious Diseases
Euna OhByeonghwa Jeon

Abstract

Campylobacter jejuni, a major cause of bacterial foodborne illnesses, is considered highly susceptible to environmental stresses. In this study, we extensively investigated the stress tolerance of 121 clinical strains of C. jejuni against 5 stress conditions (aerobic stress, disinfectant exposure, freeze-thaw, heat treatment, and osmotic stress) that this pathogenic bacterium might encounter during foodborne transmission to humans. In contrast to our current perception about high stress sensitivity of C. jejuni, a number of clinical strains of C. jejuni were highly tolerant to multiple stresses. We performed population genetics analysis by using comparative genomic fingerprinting and showed that multistress-tolerant strains of C. jejuni constituted distinct clades. The comparative genomic fingerprinting subtypes belonging to multistress-tolerant clades were more frequently implicated in human infections than those in stress-sensitive clades. We identified unique stress-tolerant C. jejuni clones and showed the role of stress tolerance in human campylobacteriosis.

References

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Citations

Sep 15, 2019·Applied and Environmental Microbiology·Lesley GoodSophia Kathariou
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Arturo B SoroBrijesh K Tiwari

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Methods Mentioned

BETA
chemical treatment
PCR

Software Mentioned

BioNumerics
SPSS

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