Frequent inadequate supply of micronutrients in fast food induces oxidative stress and inflammation in testicular tissues of weanling rats

The Journal of Pharmacy and Pharmacology
Mohamed M El-SeweidyRasha H Mohamed

Abstract

Fast food is high in energy density and low in essential micronutrient density, especially zinc (Zn), of which antioxidant processes are dependent. We have tested the hypothesis that frequent fast food consumption could induce oxidative damage associated with inflammation in weanling male rats in relevance to Zn deprivation, which could adversely affect testis function. Zn and iron (in plasma and testicular tissue), plasma antioxidant vitamins (A, E, and C), as well as testicular superoxide dismutase (SOD) and reduced glutathione (GSH), lipid peroxidation indexes (thiobarbituric acid reactive substances (TBARS) and lipoprotein oxidation susceptibility (LOS)), and inflammatory markers (plasma C-reactive protein (CRP) and testicular tumour necrosis factor-alpha (TNF-alpha)) were determined. Serum testosterone and histological examination of the testis were performed also. We found a severe decrease in antioxidant vitamins and Zn, with concomitant iron accumulation. Zinc deficiency correlated positively with SOD, GSH, antioxidant vitamins and testosterone, and negatively with TBARS, LOS, CRP and TNF-alpha, demonstrating a state of oxidative stress and inflammation. We concluded that micronutrient deficiency, especially Zn, enhance...Continue Reading

References

Oct 1, 1991·Archives of Histology and Cytology·H UedaS Fujimoto
Oct 15, 1991·Biochimica Et Biophysica Acta·I JialalS M Grundy
Jul 15, 1994·Experientia·R S Bedwal, A Bahuguna
Apr 29, 1998·Journal of the American College of Nutrition·H G PreussR A Anderson
Aug 13, 1998·The American Journal of Clinical Nutrition·P Christian, K P West
Feb 8, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M A El-Missiry
Aug 30, 2002·Biochemical and Biophysical Research Communications·John J Haddad
Sep 21, 2002·Lancet·Cara B EbbelingDavid S Ludwig
Mar 4, 2003·The Journal of Nutrition·Simone A French
May 14, 2003·The Journal of Nutritional Biochemistry·Sang K Noh, Sung I Koo
Oct 2, 2003·Journal of the American Dietetic Association·Sahasporn PaeratakulGeorge A Bray
Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Luchuan CaoSalman Azhar
Mar 30, 2004·Journal of the American College of Nutrition·Shanthy A Bowman, Bryan T Vinyard
Sep 20, 2005·Annals of Clinical Biochemistry·M Ghayour-MobarhanG A A Ferns
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Paresh DandonaHusam Ghanim
Sep 18, 2007·Biological Trace Element Research·Shu-Ming ChenJyh-Fei Liao
Dec 7, 2007·Experimental Gerontology·Ananda S Prasad

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Citations

Mar 25, 2010·International Journal of Colorectal Disease·A M El-Tawil
Jan 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Maneesh MailankotD M Vasudevan
Aug 9, 2011·World Journal of Pediatrics : WJP·Jianghong LiuCharlene Compher
Feb 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yo OmataPatricia I Oteiza
Apr 20, 2016·Australian Dental Journal·M AkbariH S Mohammadipour
May 9, 2009·Journal of Psychopharmacology·P Celec, M Behuliak
May 29, 2020·Reproductive Biology and Endocrinology : RB&E·Zhanhui OuLing Sun
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Gerthe F KerkhofAnita C S Hokken-Koelega
Jan 1, 2015·Health Promotion Perspectives·Zahra BahadoranFereidoun Azizi
Feb 14, 2018·International Journal of Molecular Medicine·Li LiFulu Gao

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