PMID: 9646036Jul 1, 1998Paper

Frequent loss of heterozygosity at chromosome 13q12-13 with BRCA2 markers in sporadic male breast cancer

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
D PrechtelH Höfler

Abstract

Molecular genetic analysis indicates that the BRCA2 gene plays an important role in familial male breast cancer. To determine a possible involvement of this tumor suppressor gene in sporadic male breast cancer, we examined 30 sporadic male breast carcinomas for loss of heterozygosity (LOH) at two loci on chromosome 13q12-13, a region that spans the BRCA2 locus. Sixteen of 24 (67%) informative cases showed LOH in at least one marker on chromosome 13q12-13. The affected cases included both invasive ductal carcinomas and other types of invasive breast carcinoma and were detected preferentially in patients who were 50 years or older, in patients with lymph node metastasis, and in progesterone receptor-negative cases. We report, for the first time, a high frequency of LOH at chromosome 13q12-13 in sporadic male breast cancer and its association with factors indicating a poor prognosis for this tumor (e.g., lymph node metastasis and negative progesterone receptor status). These findings suggest an important role for BRCA2 in the development and progression of sporadic male breast cancer.

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Citations

Feb 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K J Ruddy, E P Winer
Feb 24, 2011·AJR. American Journal of Roentgenology·Elaine IuanowPriscilla J Slanetz
Jul 18, 2008·Cancer Detection and Prevention·Maria Nowacka-ZawiszaWanda M Krajewska
Dec 22, 2007·Journal of Cutaneous Pathology·Sarah E GrayMohamed Mabruk
Jul 30, 1999·Journal of the American Academy of Dermatology·R Happle
May 31, 2002·Expert Opinion on Pharmacotherapy·Teresa Hayes
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Eliza KwiatkowskaAndrzej Mackiewicz
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Christian RudlowskiLászló Füzesi

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