Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung

Pathology International
Taichiro YoshimotoToshiro Niki

Abstract

The switch/sucrose non-fermenting (SWI/SNF) complex has recently emerged as a novel tumor suppressor in various human cancers. In the present study, we analyzed the expression of multiple SWI/SNF subunits in primary non-small cell lung cancer (NSCLC). A total of 133 NSCLC, consisting of 25 squamous cell carcinomas (SCC), 70 adenocarcinomas (AD), 16 large cell carcinomas (LC), and 22 pleomorphic carcinomas (PL), were immunohistochemically examined for the expression of BRG1, BRM, BAF47, ARID1A, and ARID1B. The frequency at which reductions in the expression of BRG1 were observed was significantly higher in the LC-PL group (13/38, 34.2%) than in the SCC-AD group (7/95, 7.4%). Similarly, the frequency at which reductions in the expression of BRM were observed was significantly higher in the LC-PL group (17/38, 44.7%) than in the SCC-AD group (14/95, 14.7%). The loss of the expression of ARID1A, ARID1B, and BAF47 was observed only in a fraction of NSCLC cases. Furthermore, the frequency at which the concurrent loss of multiple subunits of the SWI/SNF complex was observed was significantly higher in the LC-PL group (10/38, 26.3%) than in the SCC-AD group (8/95, 8.4%). Collectively, these results indicate that the loss of the SWI/SNF...Continue Reading

References

Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Junya FukuokaJin Jen
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 5, 2008·Human Mutation·Pedro P MedinaMontse Sanchez-Cespedes
Dec 26, 2008·Methods in Molecular Biology·Ping Yang
Mar 17, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Valentina MonicaMauro Papotti
Jan 30, 2010·Nature·Lena Ho, Gerald R Crabtree
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Feb 4, 2011·The New England Journal of Medicine·David J BirnbaumFrançois Bertucci
Feb 4, 2011·The New England Journal of Medicine·Michael Nissenblatt
Jun 10, 2011·Nature Reviews. Cancer·Boris G Wilson, Charles W M Roberts
Nov 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Atsuko KatagiriKohji Miyazaki
Jan 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·A Hunter ShainJonathan R Pollack
Dec 5, 2012·Cancer Discovery·Jennifer N Wu, Charles W M Roberts
Aug 2, 2013·Japanese Journal of Clinical Oncology·Takahiro OikeTakashi Kohno
Jan 3, 2014·The Journal of Clinical Investigation·Nita AhujaStephen B Baylin
Jan 3, 2014·International Journal of Cancer. Journal International Du Cancer·Tatiana CajusoPia Vahteristo
Aug 30, 2014·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jaclyn A BiegelBernard E Weissman
Sep 10, 2014·Cancer Cell·Katherine C HelmingCharles W M Roberts
Sep 24, 2014·Cancer Genetics·Ashley S Margol, Alexander R Judkins
Dec 7, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·So MiyaharaKazuki Nabeshima
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson

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Citations

Mar 4, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiko YoshidaNobuyoshi Hiraoka
Jul 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Naoki OishiRyohei Katoh
Sep 7, 2018·Advances in Anatomic Pathology·Yin P Hung, Lynette M Sholl
Jun 24, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L SauterJennifer M Boland
Aug 7, 2019·International Journal of Surgical Pathology·Brian D StewartPetr Starostik
Sep 15, 2017·Clinical Epigenetics·Abril Marcela Herrera-SolorioFederico Ávila-Moreno
Jun 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yin P HungLynette M Sholl
Nov 22, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Natasha RekhtmanWilliam D Travis
Jan 10, 2020·Bulletin du cancer·Elise DecroixAudrey Mansuet-Lupo
Aug 22, 2020·Pathology, Research and Practice·Si-Hyong JangMee-Hye Oh
Apr 16, 2021·Cancer Research·Anthony M MusolfJoan E Bailey-Wilson

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