Abstract
The switch/sucrose non-fermenting (SWI/SNF) complex has recently emerged as a novel tumor suppressor in various human cancers. In the present study, we analyzed the expression of multiple SWI/SNF subunits in primary non-small cell lung cancer (NSCLC). A total of 133 NSCLC, consisting of 25 squamous cell carcinomas (SCC), 70 adenocarcinomas (AD), 16 large cell carcinomas (LC), and 22 pleomorphic carcinomas (PL), were immunohistochemically examined for the expression of BRG1, BRM, BAF47, ARID1A, and ARID1B. The frequency at which reductions in the expression of BRG1 were observed was significantly higher in the LC-PL group (13/38, 34.2%) than in the SCC-AD group (7/95, 7.4%). Similarly, the frequency at which reductions in the expression of BRM were observed was significantly higher in the LC-PL group (17/38, 44.7%) than in the SCC-AD group (14/95, 14.7%). The loss of the expression of ARID1A, ARID1B, and BAF47 was observed only in a fraction of NSCLC cases. Furthermore, the frequency at which the concurrent loss of multiple subunits of the SWI/SNF complex was observed was significantly higher in the LC-PL group (10/38, 26.3%) than in the SCC-AD group (8/95, 8.4%). Collectively, these results indicate that the loss of the SWI/SNF...Continue Reading
References
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Junya FukuokaJin Jen
Feb 8, 2006·The Journal of Pathology·K TsutaA Ochiai
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 5, 2008·Human Mutation·Pedro P MedinaMontse Sanchez-Cespedes
Dec 26, 2008·Methods in Molecular Biology·Ping Yang
Mar 17, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Valentina MonicaMauro Papotti
Jan 30, 2010·Nature·Lena Ho, Gerald R Crabtree
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Feb 4, 2011·The New England Journal of Medicine·David J BirnbaumFrançois Bertucci
Feb 4, 2011·The New England Journal of Medicine·Michael Nissenblatt
Jun 10, 2011·Nature Reviews. Cancer·Boris G Wilson, Charles W M Roberts
Nov 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Atsuko KatagiriKohji Miyazaki
Jan 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·A Hunter ShainJonathan R Pollack
Nov 21, 2012·Cancer Science·Daisuke MatsubaraToshiro Niki
Dec 5, 2012·Cancer Discovery·Jennifer N Wu, Charles W M Roberts
Aug 2, 2013·Japanese Journal of Clinical Oncology·Takahiro OikeTakashi Kohno
Nov 20, 2013·Genetic Epidemiology·Anja SchoepsJenny Chang-Claude
Jan 3, 2014·The Journal of Clinical Investigation·Nita AhujaStephen B Baylin
Jan 3, 2014·International Journal of Cancer. Journal International Du Cancer·Tatiana CajusoPia Vahteristo
Aug 20, 2014·Cancer Research·Takahiro OikeTakashi Kohno
Aug 30, 2014·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jaclyn A BiegelBernard E Weissman
Sep 10, 2014·Human Pathology·Li LiXiao-Jun Zhou
Sep 10, 2014·Cancer Cell·Katherine C HelmingCharles W M Roberts
Sep 24, 2014·Cancer Genetics·Ashley S Margol, Alexander R Judkins
Dec 7, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·So MiyaharaKazuki Nabeshima
Dec 17, 2014·Histopathology·Qiu RaoXiao-jun Zhou
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson
Citations
Mar 4, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiko YoshidaNobuyoshi Hiraoka
Jul 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Naoki OishiRyohei Katoh
Sep 7, 2018·Advances in Anatomic Pathology·Yin P Hung, Lynette M Sholl
Jun 24, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L SauterJennifer M Boland
Aug 7, 2019·International Journal of Surgical Pathology·Brian D StewartPetr Starostik
Feb 12, 2020·PloS One·Isa MambetsarievRavi Salgia
Aug 12, 2017·Oxidative Medicine and Cellular Longevity·Mian GeZiqing Hei
Sep 15, 2017·Clinical Epigenetics·Abril Marcela Herrera-SolorioFederico Ávila-Moreno
Nov 15, 2019·Epigenetics & Chromatin·Iga JancewiczElzbieta Sarnowska
Jun 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yin P HungLynette M Sholl
Apr 29, 2020·Histopathology·Shih-Chiang HuangTse-Ching Chen
Mar 16, 2017·Molecular Cancer Therapeutics·Elayne Chan-PenebreScott A Ribich
Nov 22, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Natasha RekhtmanWilliam D Travis
Jan 10, 2020·Bulletin du cancer·Elise DecroixAudrey Mansuet-Lupo
Feb 10, 2019·Annales de pathologie·Clémence YguelGuillaume Gauchotte
Dec 24, 2018·Genomics·Chuanjia YangDongxu Cui
Aug 22, 2020·Pathology, Research and Practice·Si-Hyong JangMee-Hye Oh
Apr 16, 2021·Cancer Research·Anthony M MusolfJoan E Bailey-Wilson
Jun 24, 2019·Acta Cytologica·Lily MeiTatjana Antic