Frequent low-dose misoprostol for termination of second-trimester pregnancy

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
S DilbazB G Kahraman

Abstract

To determine the efficacy of an application regimen of low-dose frequent misoprostol for second-trimester pregnancy termination. A total of 250 women between 12 and 20 weeks of gestation who were scheduled for second-trimester pregnancy termination received 200 microg vaginal misoprostol followed by 100 microg oral misoprostol every 2 h until expulsion of the fetus. Mechanical cervical dilatation with a 16-French Foley balloon catheter was performed if no cervical dilatation was observed after 24 h. The main outcome measures were the delivery rate within 24 h and the factors influencing the interval between the onset of induction and abortion. Secondary outcome measures were the side-effects of the regimen and the total misoprostol dose required. With application of this protocol, 245 women (98%) delivered within 24 h of induction. The mean (+/-standard deviation) misoprostol dose used was 728+/-297 microg (200-2100 microg). Cox regression analysis revealed that vaginal spotting or nulliparity do not effect the induction-abortion time. On the other hand, using this regimen induction to abortion time tends to be longer in the presence of live fetuses (odds ratio (OR) = 0.45; confidence interval (CI) =0.2-0.8; p=0.008) and pregna...Continue Reading

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Citations

Feb 26, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Eray CaliskanIzzet Yucesoy
Feb 26, 2011·The Journal of Obstetrics and Gynaecology Research·Talat Umut Kutlu DilekSaffet Dilek
Nov 30, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·U EsenA Jones

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