PMID: 8589035Nov 1, 1995Paper

Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas

Genes, Chromosomes & Cancer
D BartschP J Goodfellow

Abstract

The gene encoding the cell-cycle regulatory protein p16, CDKN2, is localized on chromosome band 9p21. CDKN2 is frequently deleted or mutated in a variety of tumor cell lines, including pancreatic cancer cell lines and xenografts, as well as in some primary tumors. We examined 32 primary pancreatic adenocarcinomas for CDKN2 mutations and for loss of heterozygosity of 9p21 sequences to assess the role of CDKN2 in pancreatic carcinogenesis. Single-strand conformation variant analysis (SSCV) and direct sequencing of the variants revealed somatic CDKN2 mutations in 11 of 32 tumors (five frame-shift mutations, five nonsense mutations, and one missense mutation). One tumor appeared to be characterized by homozygous deletion of CDKN2. These results suggest that CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas.

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Citations

Jan 1, 1996·Molecular Carcinogenesis·W S TungP J Goodfellow
Jan 1, 1997·Journal of Clinical Laboratory Analysis·T M Chu
Apr 19, 1996·Cancer Letters·D BartschP J Goodfellow
Jan 1, 1997·Surgical Oncology·J R Howe, K C Conlon
Aug 10, 2000·The British Journal of Surgery·M ManuS Bramhall
Aug 1, 2012·The Cancer Journal·Jennifer E Axilbund, Elizabeth A Wiley
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Donna E HanselRalph H Hruban
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lydie CostentinNicole Vaysse
Oct 1, 1996·Leukemia & Lymphoma·M Heyman, S Einhorn
Oct 15, 2010·Expert Review of Anticancer Therapy·Rizwan SheikhRay McDermott
Feb 1, 2006·Journal of Cellular Physiology·Claudia AugelloAntonio Russo
Jun 27, 2012·Genes, Chromosomes & Cancer·Annabelle L FonsecaTobias Carling
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
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Jun 18, 2021·World Journal of Gastroenterology : WJG·Michela VisaniDario de Biase

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