PMID: 8600078Jul 1, 1995Paper

Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
H TsudaS Hirohashi

Abstract

The frequency of c-Ki-ras mutation was examined by polymerase chain reaction (single-strand conformation polymorphism and direct sequencing analysis) and its association with histological parameters was analyzed in 110 endometrial adenocarcinoma hysterectomy specimens. The c-Ki-ras mutation was detected in 24 cases (22%). It occurred irrespective of tumor size, stage or histological grade, and was more frequent in tumors associated with endometrial hyperplasia (11 of 20, 55%) than in those without (10 of 73, 14%). In addition, the frequency of the mutation was significantly higher in tumors showing an infiltrative growth pattern accompanied by a stromal response consisting of edematous fibrous tissue (19 of 58, 33%), than in those which revealed an expansive growth pattern without such a stromal reaction (five of 52, 10%). Even among tumors showing the infiltrative growth pattern, the frequency of c-Ki-ras mutation was especially high (48%) in grade I cases in comparison with grade II or III cases (20% and 19%). Mutational activation of the c-Ki-ras gene may act at two points in the developmental pathway of endometrial adenocarcinoma by enhancing evolution of hyperplasia to adenocarcinoma, and by producing an infiltrative growt...Continue Reading

Citations

Feb 17, 2001·The Journal of Pathology·H LagardaJ Prat
Oct 21, 2009·DNA and Cell Biology·Darina KonstantinovaVanio Mitev
May 19, 2005·American Journal of Clinical Pathology·Hemamali SamaratungaDavid Purdie
Dec 7, 2007·Obstetrics and Gynecology Clinics of North America·Dana EspindolaEdgar G Fischer
Aug 19, 2014·The Journal of Obstetrics and Gynaecology Research·Kouji BannoDaisuke Aoki
Mar 17, 2007·Pathology·Jaime PratLluis Catasús
Apr 4, 2021·Cancers·Lisa Maria MustachioJason Roszik

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