Abstract
Oxacillin-susceptible mecA-positive Staphylococcus aureus (OS-MRSA) isolates have been increasingly reported worldwide, but data regarding the African continent have not been available. Between 2010 and 2014, 1462 inpatients and healthcare workers were screened for MRSA nasal carriage in São Tomé and Príncipe (STP) and Angola, two Portuguese-speaking African countries (PALOP countries). We determined the presence of the mecA gene and the antimicrobial susceptibility profiles of the isolates. OS-MRSA clonal lineages were identified as well as the presence of virulence determinants, including Panton-Valentine leucocidin (PVL). Out of 164 S. aureus hospital isolates tested, 29 (17.7%) were mecA positive, but susceptible to oxacillin, showing oxacillin MICs ≤3 mg/L. All OS-MRSA isolates were resistant to cefoxitin and most of them were also resistant to at least two antimicrobials other than β-lactams. The 29 OS-MRSA were distributed into two major clonal lineages: (i) PFGE type B-ST88-SCCmec IVa, associated with spa types t186/t325/t786/t1814/t1951, detected in Angola (n = 5) and STP (n = 10); and (ii) PFGE type C-t451/t648-ST8-SCCmec V, exclusively found in STP (n = 9). OS-MRSA showed at least two virulence determinants. PVL was ...Continue Reading
References
Oct 30, 2001·Journal of Clinical Microbiology·G SakoulasQ Qian
Nov 1, 2002·Journal of Clinical Microbiology·Keiko OkumaKeiichi Hiramatsu
Dec 4, 2002·The Journal of Antimicrobial Chemotherapy·E PetinakiA N Maniatis
Sep 12, 2003·Emerging Infectious Diseases·Francois VandeneschJerome Etienne
Nov 8, 2005·Internal Medicine Journal·C Rayner, W J Munckhof
Feb 23, 2007·Journal of Medical Microbiology·Gurdal YilmazIftihar Koksal
Apr 27, 2007·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yasuko HososakaKeisuke Sunakawa
Oct 6, 2007·Letters in Applied Microbiology·M CorrenteC Buonavoglia
Apr 1, 2008·Journal of Bacteriology·Raymond RuimyEdward J Feil
May 30, 2008·Diagnostic Microbiology and Infectious Disease·Betty A ForbesAdriana E Rosato
Jul 3, 2009·Journal of Clinical Microbiology·B GhebremedhinW König
Mar 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S BreurecB Garin
May 7, 2011·BMC Microbiology·Adebayo O ShittuUlrich Nübel
Mar 2, 2012·Journal of Clinical Microbiology·Feng-Jui ChenUNKNOWN TSAR Hospitals
Mar 13, 2012·The Journal of Infection·Pak-Leung HoYu-Lung Lau
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Maria LabrouAthanassios Tsakris
Sep 21, 2012·Journal of Clinical Microbiology·Katie A SharffMargret Oethinger
Oct 10, 2012·Current Opinion in Microbiology·José R MediavillaBarry N Kreiswirth
Nov 9, 2012·Journal of Clinical Microbiology·V Anil KumarRaja Biswas
Sep 3, 2013·Diagnostic Microbiology and Infectious Disease·Wenqiang HeHui Wang
Sep 13, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Teresa ConceiçãoMarta Aires-de-Sousa
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F SchaumburgK Becker
Feb 14, 2014·PloS One·WanXia PuChunXia Ni
Apr 4, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Teresa ConceiçãoMarta Aires-de-Sousa
Jun 13, 2014·Infection·K SaeedS Green
Mar 12, 2015·Current Pharmaceutical Design·Spyros PournarasAlexander W Friedrich
May 25, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T ConceiçãoM Aires-de-Sousa
Dec 1, 2013·Journal of Global Antimicrobial Resistance·Beverly EgyirAnders Rhod Larsen
Citations
Jun 10, 2016·The Journal of Antimicrobial Chemotherapy·Marilyn ChungAlexander Tomasz
Apr 23, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PhakuF Schaumburg
Aug 25, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K V OkudaR Berner
Nov 5, 2016·Diagnostic Microbiology and Infectious Disease·Cheng-Mao HoJang-Jih Lu
Feb 14, 2020·PloS One·Wenjing GengAnne-Catrin Uhlemann
Dec 18, 2019·The Journal of Antimicrobial Chemotherapy·Alice WegenerEls M Broens
Oct 28, 2019·Annals of the New York Academy of Sciences·John Osei Sekyere, Eric Mensah
Sep 8, 2016·PloS One·Hiral MistryVasundhra Bhandari
Jul 12, 2016·Toxins·Catherine Dunyach-RemyJean-Philippe Lavigne
Nov 7, 2019·Scientific Reports·Umarani BrahmaVasundhra Bhandari
Oct 11, 2020·Scientific Reports·Tanit BoonsiriLongzhu Cui
Jan 1, 2021·Frontiers in Microbiology·Sara A OchoaJuan Xicohtencatl-Cortes
Feb 12, 2021·Annals of Clinical Microbiology and Antimicrobials·Nathalia Bibiana TeixeiraMaria de Lourdes Ribeiro de Souza da Cunha