Frequent sequence exchanges between homologs of RPP8 in Arabidopsis are not necessarily associated with genomic proximity

The Plant Journal : for Cell and Molecular Biology
Hanhui KuangRichard W Michelmore

Abstract

Disease resistance (R) genes are often clustered in plant genomes and may exhibit heterogeneous rates of evolution. Some (type I R genes) have evolved rapidly through frequent sequence exchanges, while others (type II R genes) have evolved independently and tend to be conserved in different genotypes or related species. The RPP8 resistance gene in Arabidopsis thaliana is located at a complex locus that also harbors the sequence-related resistance genes HRT and RCY1 in different ecotypes. We sequenced 98 homologs of RPP8 from A. thaliana, Arabidopsis arenosa and Arabidopsis lyrata. Three lineages of type II and one lineage of type I RPP8 homologs were identified. Two of the three lineages of type II genes are each represented by a single-copy locus on either chromosomes I or V. Chromosome V contains two small clusters of RPP8 paralogs. One cluster contains both type I and type II genes and the other comprises only type I genes. These multi-copy loci have expanded and contracted through unequal crossovers, which have generated chimeric genes as well as variations in copy number. Sequence exchanges, most likely gene conversions, were detected between RPP8 homologs that are spatially separated by 2.2 Mb and 12 cM. The sequence exch...Continue Reading

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Citations

Nov 17, 2010·Molecular Genetics and Genomics : MGG·Xiaohui ZhangJian-Qun Chen
Aug 20, 2011·Nature Immunology·Takaki MaekawaPaul Schulze-Lefert
Aug 18, 2010·Molecular Biology and Evolution·Sha LuoHanhui Kuang
Sep 22, 2009·Genome Génome / Conseil National De Recherches Canada·Yolanda LoarceEsther Ferrer
May 21, 2013·Annual Review of Phytopathology·Richard W MichelmoreKatherine S Caldwell
Aug 21, 2012·BMC Genetics·Kejing WuSihai Yang
May 18, 2011·BMC Genomics·Alessandra F RibasPhilippe Lashermes
Jul 18, 2015·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jing SuXiaoyuan Zhu
Apr 23, 2010·The Plant Journal : for Cell and Molecular Biology·Marc T Nishimura, Jeffery L Dangl
May 27, 2015·Molecular Genetics and Genomics : MGG·Zhengqing XieSihai Yang
May 18, 2016·Molecular Biology and Evolution·Xiao-Qin SunYue-Yu Hang
Jul 16, 2016·PLoS Genetics·Kyuha ChoiIan R Henderson
May 10, 2011·Vector Borne and Zoonotic Diseases·Veronique ChevalierBenoit Durand
Aug 23, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Mian WuBin Wang
Oct 19, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Fang-Fang MaBin Wang
Sep 11, 2019·Genes·Alice MacQueenJoy Bergelson
Sep 25, 2020·The New Phytologist·Wei-Lin WanEunyoung Chae

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