Fresh and Frozen-Thawed Embryo Transfer Compared to Natural Conception: Differences in Perinatal Outcome

Gynecologic and Obstetric Investigation
Suzanne SpijkersCornelis B Lambalk

Abstract

To compare the pregnancy outcome of singletons conceived after transfer of cryopreserved and thawed embryos (frozen embryo transfer [FET]) to singletons conceived after fresh embryo transfer (fresh ET) and natural conceived singletons. Using a retrospective data analysis on a study population consisting of 1,261 singletons born after FET and 2,519 singletons born after fresh ET between 2006 and 2015. The control group consisted of singletons born after natural conception. Main outcome measures consisted of birth weight (in grams), gestational age, preterm birth (<37 weeks of gestation), being large for gestational age (LGA, above 90th weight percentile adjusted for gestational age) and Apgar scores. Babies born after FET had an increased risk of high birth weight (adjusted OR [AOR]) 2.92; 1.503-3.482) and being LGA (AOR fresh ET vs. FET 1.47; 1.210-1.787) compared to singletons born after fresh ET, as well as higher birth weights compared to natural conceived children. Singletons born after FET have a higher risk of high birth weight and being LGA compared to singletons after fresh ET and compared to natural conceived singletons. We assume that the freezing process might be the underlying cause.

Citations

Jan 10, 2020·Human Reproduction·Thi T Truong, David K Gardner
Dec 17, 2019·Hypertension·Frauke von Versen-HöynckVirginia D Winn
May 10, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezFrancisco Marco-Jiménez
Jun 19, 2018·Human Reproduction Update·Edgardo SomiglianaPaola Viganò
Mar 11, 2020·Frontiers in Endocrinology·Ernesto BoschPeter Humaidan
Jun 21, 2020·Animals : an Open Access Journal From MDPI·Ximo Garcia-DominguezJosé Salvador Vicente
Jul 22, 2018·Journal of Assisted Reproduction and Genetics·Junshun FangLinjun Chen
Feb 5, 2021·The Cochrane Database of Systematic Reviews·Tjitske ZaatSebastiaan Mastenbroek
Mar 20, 2021·Reproductive Biomedicine Online·Tjitske R ZaatUNKNOWN ANTARCTICA trial study group
Aug 9, 2021·Theriogenology·Lucy May ViningKatie Evelyn Harvey

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