Fresh approaches to antibiotic production

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
D A Hopwood, K F Chater

Abstract

New antibiotics are needed, (a) to control diseases that are refractory to existing ones either because of intrinsic or acquired drug resistance of the pathogen or because inhibition of the disease is difficult, at present, without damaging the host (fungal and viral diseases, and tumours), (b) for the control of plant pathogens and of invertebrates such as helminths, insects, etc., and (c) for growth promotion in intensive farming. Numerous new antibiotics are still being obtained from wild microbes, especially actinomycetes. Chemical modification of existing compounds has also had notable success. Here we explore the uses, actual and potential, of genetics to generate new antibiotics and to satisfy the ever-present need to increase yield. Yield improvement has depended in the past on mutation and selection, combined with optimization of fermentation conditions. Progress would be greatly accelerated by screening random recombinants between divergent high-yielding strains. Strain improvement may also be possible by the introduction of extra copies of genes of which the products are rate-limiting, or of genes conferring beneficial growth characteristics. Although new antibiotics can be generated by mutation, either through distu...Continue Reading

Citations

Jan 1, 1983·Molecular & General Genetics : MGG·J S Feitelson, D A Hopwood
Jun 26, 2007·Bioscience, Biotechnology, and Biochemistry·Kozo Ochi
Jan 23, 2016·Frontiers in Microbiology·Ana Lúcia Leitão, Francisco J Enguita
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Feb 8, 2002·Nature·Ying-Xin ZhangStephen B del Cardayré
Aug 31, 1989·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D A Hopwood
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