Fresh bone marrow and periosteum transplantation for cartilage defects of the knee

Transplantation Proceedings
K SlynarskiJ Karpinski

Abstract

The aim of work was to analyze clinical effectiveness of fresh bone marrow and periosteum transplantation in the treatment of traumatic or degenerative cartilage defects. The 14 patients in this study had a mean age of 37 years. Bone marrow aspirated from the iliac crest was implanted under the periosteum sutured over the defect. Three, 6, and 12 months postoperatively, the patients were evaluated with the analogue pain scale, modified Cincinnati score, and IKDC questionnaires. All patients were evaluated with magnetic resonance imaging (MRI) at 3 and 12 months postoperatively. After 3 and 6 months significant improvement was observed in eight patients. After 12 months, 12 patients were classified as normal or nearly normal in the IKDC examination form, and two as abnormal. Mean IKDC Subjective Knee Score was 86.57. MRI findings revealed surfaces with correct contours and continuity, without changes in subchondral bone in all but one patient. There was a correlation between a large size of defect or an osteoarthritic nature of the changes and poor results.

References

Apr 13, 2001·Osteoarthritis and Cartilage·Y ItoS W O'Driscoll
Aug 5, 2016·Journal of Clinical Orthopaedics and Trauma·Christoph Erggelet, P Vavken

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Citations

Jul 10, 2014·International Orthopaedics·Antonio MarmottiGiuseppe Peretti
Jan 23, 2016·Expert Opinion on Biological Therapy·Dimitris ReissisEleftherios Tsiridis
Jan 26, 2016·Journal of Cellular and Molecular Medicine·Janina FrischMagali Cucchiarini
Sep 2, 2014·Advanced Drug Delivery Reviews·Martin J StoddartMauro Alini
Mar 1, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Shanna M WilsonMatthew B Wheeler
Jun 9, 2016·Stem Cells and Development·Janina Frisch, Magali Cucchiarini
Mar 8, 2017·Animal Biotechnology·Marcello RubessaMatthew B Wheeler
May 4, 2017·Journal of Cellular and Molecular Medicine·Janina FrischMagali Cucchiarini

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