Fresh frozen bone in femoral impaction grafting: can developments in bone regeneration improve on this?

Medical Hypotheses
Manolis Heliotis, Eleftherios Tsiridis

Abstract

Major advances in the understanding of bone regeneration have led to revolutionary applications of bone conduction and induction. Revision hip surgery is on the increase with an active, ageing population demanding increased quality of life. The technically demanding instrumentation and materials necessary for revision prosthetic hip replacements have been rapidly incorporated into clinical practice. Unfortunately, advantage has not been taken of the basic and fundamental principles of bone induction and regeneration, available for many years now. In impaction grafting for revision hip replacements where fresh frozen bone is currently used as a standard, we argue and demonstrate from the literature why this technique is biologically inferior to the results which potentially can be gained by exploiting osteoinductive grafts such as demineralised bone matrix, hydroxyapetite, and inductive factors such as bone morphogenetic proteins.

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Citations

Jan 1, 2012·Revista Brasileira De Ortopedia·Carlos Roberto GaliaCarlos Alberto Souza Macedo
Jun 7, 2008·The Journal of Arthroplasty·Anneliese D HeinerThomas D Brown
May 5, 2007·Injury·E TsiridisP V Giannoudis
Aug 30, 2014·Cell and Tissue Banking·Tiango Aguiar RibeiroCarlos Roberto Galia
Dec 5, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anneliese D HeinerThomas D Brown
Jun 9, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eleftherios TsiridisLucy DiSilvio

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