Fresh Osteochondral Allograft Transplantation: Is Graft Storage Time Associated With Clinical Outcomes and Graft Survivorship?

The American Journal of Sports Medicine
Kenneth J SchmidtWilliam D Bugbee

Abstract

Regulatory concerns and the popularity of fresh osteochondral allograft (OCA) transplantation have led to a need for prolonged viable storage of osteochondral grafts. Tissue culture media allow a longer storage time but lead to chondrocyte death within the tissue. The long-term clinical consequence of prolonged storage is unknown. Patients transplanted with OCAs with a shorter storage time would have lower failure rates and better clinical outcomes than those transplanted with OCAs with prolonged storage. Cohort study; Level of evidence, 3. A matched-pair study was performed of 75 patients who received early release grafts (mean storage, 6.3 days [range, 1-14 days]) between 1997 and 2002, matched 1:1 by age, diagnosis, and graft size, with 75 patients who received late release grafts (mean storage time, 20.0 days [range, 16-28 days]) from 2002 to 2008. The mean age was 33.5 years, and the median graft size was 6.3 cm2. All patients had a minimum 2-year follow-up. Evaluations included pain, satisfaction, function, failures, and reoperations. Outcome measures included the modified Merle d'Aubigné-Postel (18-point) scale, International Knee Documentation Committee (IKDC) form, and Knee Society function (KS-F) scale. Clinical failu...Continue Reading

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Citations

May 18, 2019·The American Journal of Sports Medicine·Luís E P TíricoWilliam D Bugbee
Sep 15, 2018·Foot & Ankle International·Niall A SmythUNKNOWN International Consensus Group on Cartilage Repair of the Ankle
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Jul 27, 2021·The American Journal of Sports Medicine·Suzanne M TabbaaWilliam D Bugbee
Jun 3, 2020·The Journal of Knee Surgery·Steven F DeFrodaBrett D Owens

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