Fresh transfer outcome predicts the success of a subsequent frozen transfer utilizing blastocysts of the same cohort

Reproductive Biomedicine Online
L F DohertyP Patrizio

Abstract

The objective of this retrospective analysis was to assess whether the outcomes of fresh blastocyst transfer cycles are predictive of the chances for pregnancy and live birth in subsequent frozen blastocyst transfer cycles using sibling embryos from the same retrieval. Clinical pregnancy rate (CPR) and live birth rate (LBR) per fresh and frozen blastocyst transfer were assessed. All subgroups had similar patient and cycle characteristics. Overall, CPR and LBR in fresh cycles were 44% and 29%, and in frozen were 34% and 30%, respectively. However, the CPR and LBR in frozen cycles were significantly higher in patients who were not pregnant with their fresh cycles (CPR 43% versus 22%, P=0.01; and LBR 36% versus 17%, P=0.03, respectively). When fresh cycles are unsuccessful, the remaining frozen blastocysts of the same cohort have the same chance of success in producing a clinical pregnancy as the fresh cycle (43% versus 44%). Frozen cycles following successful fresh cycles have significantly lower CPR and LBR. These data reinforce the concept that only a few embryos per cohort are competent for a live birth. During IVF cycles, many patients are fortunate enough to have excess high-quality embryos remaining after their embryo trans...Continue Reading

References

Jun 2, 2001·Human Reproduction·A TiitinenC Hyden-Granskog
Jan 9, 2007·Reproductive Biomedicine Online·P PatrizioD Sakkas
Mar 8, 2008·Fertility and Sterility·Pasquale Patrizio, Denny Sakkas
Jan 16, 2009·The New England Journal of Medicine·Beth A MaliziaAlan S Penzias
Mar 5, 2011·Journal of Assisted Reproduction and Genetics·Inna BerinDiane L Wright

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Citations

Sep 30, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nivin SamaraAmir Wiser
Jul 21, 2020·Human Fertility : Journal of the British Fertility Society·Anat Hershko KlementTal Shavit
Mar 22, 2019·Human Reproduction Open·N E van HoogenhuijzeH L Torrance

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