PMID: 8606518Apr 1, 1996Paper

Fresh vein allograft survival in dogs after cyclosporine treatment

The Journal of Surgical Research
A MingoliA Cavallaro

Abstract

Synthetic grafts are widely used for peripheral arterial reconstructions when autologous veins are not available, but their results have not been satisfactory. Venous allograft may be used as an alternative to synthetic prostheses. The aim of the study was to explore the immunosuppressive efficacy of Cyclosporine A (CyA) as a means of preventing venous allograft failures and rejection. We utilized 56 mongrel dogs. Immunological incompatibility was checked with the skin graft method. Donor inferior vena cava was transplanted into the infrarenal abdominal aorta of recipient animals. One group (group 1, 10 dogs) served as a control and three groups received CyA treatment regimens. Group 2 (10 dogs) received postoperative oral CyA treatment for 30 days. Group 3 (12 dogs) received a vein graft pretreated with a CyA solution without postoperative immunosuppressive therapy. Group 4 (9 dogs) received a vein graft pretreated with a CyA solution and postoperative CyA treatment for 30 days. Allografts were examined at 30 days for patency, aneurysmal dilatation, gross structural changes, inflammatory response, and lymphocytic infiltration. Sex chromatine assessment determined the origin (donor or recipient) of the endothelial cells. The al...Continue Reading

Citations

Jul 1, 1997·Journal of Vascular Surgery·J P Carpenter, J E Tomaszewski
Apr 18, 1998·Journal of Vascular Surgery·J P Carpenter, J E Tomaszewski
Jun 19, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I MatiaM Adamec
Jun 22, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M G DaviesP O Hagen
Dec 18, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I MatiaM Adamec
Jan 13, 2006·The Heart Surgery Forum·Thomas SchachnerJohannes Bonatti
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raj R ThakrarAlexander M Seifalian

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