PMID: 16532626Mar 15, 2006Paper

Frictional response of bovine articular cartilage under creep loading following proteoglycan digestion with chondroitinase ABC

Journal of Biomechanical Engineering
Ines M BasaloGerard A Ateshian

Abstract

The specific aim of this study was to investigate the effect of chondroitinase ABC treatment on the frictional response of bovine articular cartilage against glass, under creep loading. The hypothesis is that chondroitinase ABC treatment increases the friction coefficient of bovine articular cartilage under creep. Articular cartilage samples (n = 12) harvested from two bovine knee joints (1-3 months old) were divided into a control group (intact specimens) and a treated group (chondroitinase ABC digestion), and tested in unconfined compression with simultaneous continuous sliding (+/- 4 mm at 1 mm/s) under a constant applied stress of 0.5 MPa, for 2500 s. The time-dependent response of the friction coefficient was measured. With increasing duration of loading, treated samples exhibited a significantly higher friction coefficient than control samples as assessed by the equilibrium value (treated: micro(eq) = 0.19 +/- 0.02; control: micro(eq) = 0.12 +/- 0.03; p = 0.002), though the coefficient achieved immediately upon loading did not increase significantly (treated: micro(min) = 0.0053 +/- 0.0025; control: micro(min) = 0.037 +/- 0.0013; p = 0.19). Our results demonstrate that removal of the cartilage glycosaminoglycans using cho...Continue Reading

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Citations

Jun 4, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Jane DesrochersJohn R Matyas
Jan 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dong Woog LeeJacob N Israelachvili
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Nov 7, 2006·Journal of Biomechanics·Ines M BasaloGerard A Ateshian
Nov 11, 2008·Medical Engineering & Physics·Jayanth KattaJohn Fisher
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Jan 4, 2018·Biomacromolecules·Giulia MorgeseEdmondo M Benetti
May 26, 2009·Journal of Biomechanics·Gerard A Ateshian

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