Friend or foe-Post-translational modifications as regulators of phase separation and RNP granule dynamics

The Journal of Biological Chemistry
Mario Hofweber, Dorothee Dormann

Abstract

Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-binding proteins (RBPs) and RNA. RNA granules form through liquid-liquid phase separation (LLPS), whereby weak promiscuous interactions among RBPs and/or RNAs create a dense network of interacting macromolecules and drive the phase separation. Post-translational modifications (PTMs) of RBPs have emerged as important regulators of LLPS and RNP granule dynamics, as they can directly weaken or enhance the multivalent interactions between phase-separating macromolecules or can recruit or exclude certain macromolecules into or from condensates. Here, we review recent insights into how PTMs regulate phase separation and RNP granule dynamics, in particular arginine (Arg)-methylation and phosphorylation. We discuss how these PTMs regulate the phase behavior of prototypical RBPs and how, as "friend or foe," they might influence the assembly, disassembly, or material properties of cellular RNP granules, such as stress granules or amyloid-like condensates. We particularly highlight how PTMs control the phase separation and aggregation behavior of disease-linked RBPs. We also review how disruptions of PTMs might be involved in aberrant phase transitions and the...Continue Reading

References

May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Mar 14, 2000·The Journal of Biological Chemistry·J TangH R Herschman
Mar 19, 2003·The Journal of Cell Biology·Helene TourrièreJamal Tazi
Nov 2, 2004·Journal of Neural Transmission·C-X GongK Iqbal
Mar 23, 2005·Nature Methods·Shao-En OngMatthias Mann
Nov 1, 2005·Trends in Biochemical Sciences·Frank O Fackelmayer
Apr 26, 2006·Journal of Cell Science·Natalia DolzhanskayaRobert B Denman
Jul 19, 2006·Molecular and Cellular Biology·Sonia GuilJavier F Cáceres
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
May 10, 2008·Expert Review of Proteomics·Nicolas SergeantLuc Buée
Jun 12, 2008·Annals of Neurology·Masato HasegawaHaruhiko Akiyama
Jul 29, 2008·FEBS Letters·Yuki InukaiMasato Hasegawa
Jan 14, 2009·Acta Neuropathologica·Tetsuaki AraiHaruhiko Akiyama
Jan 20, 2009·Molecular Cell·Mark T Bedford, Steven G Clarke
Mar 17, 2009·Biochemical and Biophysical Research Communications·Fuyuki KametaniMasato Hasegawa
Nov 5, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sergi ArandaSusana de la Luna
Jul 26, 2011·Journal of Molecular Neuroscience : MN·Michel Goedert, Maria Grazia Spillantini
Aug 19, 2011·PloS One·Huei-Ying LiBenjamin Pang-hsien Tu
May 23, 2012·RNA Biology·Ken MatsumotoMasafumi Tsujimoto
May 31, 2012·Molecular & Cellular Proteomics : MCP·Jonathan C TrinidadAlma L Burlingame
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara VanderweydeBenjamin Wolozin
Jun 30, 2012·Ageing Research Reviews·Ludovic MartinFaraj Terro

❮ Previous
Next ❯

Citations

Jun 18, 2019·Traffic·Nadia FormicolaFlorence Besse
Aug 23, 2019·Journal of Assisted Reproduction and Genetics·David F Albertini
Oct 14, 2019·Traffic·Stephanie SpannlHyun O Lee
Dec 14, 2019·The Journal of Cell Biology·Dorothee Dormann
May 4, 2020·Wiley Interdisciplinary Reviews. RNA·Klára FrydrýškováMartin Pospíšek
May 5, 2020·Emerging Topics in Life Sciences·Richard John Wheeler
Feb 1, 2020·Annual Review of Biophysics·Jeong-Mo ChoiRohit V Pappu
May 14, 2020·The Journal of Cell Biology·Therese M GerbichAmy S Gladfelter
Jun 24, 2020·Emerging Topics in Life Sciences·M Sankaranarayanan, Timothy T Weil
Jun 3, 2020·ELife·Srivastav Ranganathan, Eugene I Shakhnovich
Jun 3, 2020·Cold Spring Harbor Symposia on Quantitative Biology·Giulia Ada Corbet, Roy Parker
Aug 4, 2020·Emerging Topics in Life Sciences·Maria HondeleKarsten Weis
Sep 3, 2020·Briefings in Bioinformatics·Chunyu YuTingting Li
Apr 25, 2020·The Journal of Cell Biology·Jean A SmithJimena Giudice
Jun 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lu ZhangHening Lin
Jun 18, 2020·Science China. Life Sciences·Hong ZhangXueliang Zhu
Sep 17, 2020·Biomolecules·Kathi ZarnackKatja Sträßer
Sep 19, 2020·Molecular & Cellular Oncology·Roberto Giambruno, Tiziana Bonaldi
Aug 11, 2019·Nature Communications·Jenifer E ShattuckEric D Ross
Dec 12, 2019·Frontiers in Molecular Biosciences·Kavya Vinayan Pushpalatha, Florence Besse
Aug 5, 2020·Acta Neuropathologica·Alexander BamptonAriana Gatt
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xinrong MaHeriberto Cerutti
Jun 18, 2020·Frontiers in Molecular Neuroscience·Yuan Chao XueHonglin Luo
Jul 10, 2019·International Journal of Molecular Sciences·Melody D FultonY George Zheng
Jun 15, 2019·Nature Communications·Jeshlee VijayakumarFlorence Besse
Nov 21, 2019·Current Genetics·Jenifer E ShattuckEric D Ross
Sep 17, 2020·Nature Communications·Rachel S Fisher, Shana Elbaum-Garfinkle
Sep 11, 2020·Soft Matter·Mengying WangChristian Betzel
May 19, 2019·Cellular and Molecular Life Sciences : CMLS·Benjamin M Lorton, David Shechter
Nov 7, 2019·International Journal of Molecular Sciences·Izzy Owen, Frank Shewmaker
Oct 21, 2020·Emerging Topics in Life Sciences·Erik W Martin, Alex S Holehouse
Aug 6, 2019·Neuron·Matthew G AndrusiakYishi Jin
Nov 11, 2020·The Journal of Biological Chemistry·Ameya P JalihalNils G Walter
Jan 10, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·James BarrettLuke C M Mackinder
Feb 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Aravinth Kumar JayabalanAnthony K L Leung
Feb 9, 2021·Wiley Interdisciplinary Reviews. RNA·Nivedita Mukherjee, Chandrama Mukherjee
Nov 4, 2020·ELife·Shan JiangBeidong Liu
Feb 8, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·April L Darling, James Shorter

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