PMID: 16628002Apr 22, 2006Paper

Friend or foe? The proteasome in combined cancer therapy

Cell Cycle
Dennis SohnReiner U Jänicke

Abstract

The proteasome is a multicatalytic enzyme complex that is responsible for degradation of the vast majority of intracellular proteins. Thus, it is involved in diverse cellular processes such as proliferation, differentiation and apoptosis. Especially its latter function yielded in the development of specific proteasomal inhibitors which have recently entered clinical trials due to their tremendous apoptosis-inducing capability. However, several recent studies including ours provided substantial evidence that a combined treatment of tumors with apoptosis-inducing agents and proteasomal inhibitors might even cause adverse effects leading to a prolonged survival of tumor cells. Based on our model of a biphasic role for the proteasome in apoptosis, we believe that a successful combat of tumors that relies on a combinational therapy with proteasomal inhibitors requires careful evaluation of several critical aspects in order to avoid a friend becoming a foe.

Citations

Feb 14, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·V A KulichkovaI M Konstantinova
May 4, 2010·Cancer Cell International·Thanemozhi G NatarajanKevin T FitzGerald
Aug 12, 2009·Cancer Cell International·Yiannis DrososVassiliki Aleporou-Marinou
Jul 1, 2008·Breast Cancer Research : BCR·Anna GitCarlos Caldas

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