Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?

Frontiers in Cellular and Infection Microbiology
R M StillingJ F Cryan

Abstract

The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain function and behavior. In this hypothesis and theory article, we propose how host-microbe associations potentially influenced mammalian brain evolution and development. In particular, we explore the integration of human brain development with evolution, symbiosis, and RNA biology, which together represent a "social triangle" that drives human social behavior and cognition. We argue that, in order to understand how inter-kingdom communication can affect brain adaptation and plasticity, it is inevitable to consider epigenetic mechanisms as important mediators of genome-microbiome interactions on an individual as well as a transgenerational time scale. Finally, we unite these interpretations with the hologenome theory of evolution. Taken together, we propose a tighter integration of neuroscience fields with host-associated microbiology by taking an evolutionary perspective.

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Citations

Jan 23, 2016·Frontiers in Molecular Neuroscience·Antonio Benítez-Burraco, Juan Uriagereka
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Methods Mentioned

BETA
cesarean section
acetylation
histone acetylation

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