From A to AB: A Caucasian Mother with High Anti-B Titer Causing Hemolytic Disease of the Newborn.

Laboratory Medicine
Nathanael SchooleyMoritz Stolla


We report on a term infant with clinically significant hemolysis and hyperbilirubinemia. Testing revealed ABO incompatibility between maternal type A and infant type AB. The maternal alloantibody screen was negative. The infant's direct antiglobulin test was positive, and anti-B IgG was eluted off the infant's red blood cells (RBCs). Testing of the mother's plasma revealed a high anti-B titer. The infant was successfully treated with phototherapy and intravenous immunoglobulin. The bilirubin and hematocrit stabilized, and the infant was discharged home. This case was unusual because of its severity and unusual ABO constellation. Furthermore, this report is an exemplary educational case study on how effective collaboration between the clinical team and the blood bank laboratory is critical in reaching the correct diagnosis. In summary, the differential diagnosis of more unusual and atypical ABO-incompatible constellations must be considered when an infant presents with unexplained hemolysis.


Jan 1, 1976·Transfusion·F J Grundbacher
Sep 1, 1974·Annals of Tropical Medicine and Parasitology·S WorlledgeL Luzzatto
Jan 1, 1968·Vox Sanguinis·A ChattorajA M Josephson
Jan 16, 1998·Immunology and Cell Biology·N J WuttkeH Zola
Aug 26, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·M McDonnellS P Devane
Sep 7, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·A Greenough
Jan 1, 1958·Acta Pathologica Et Microbiologica Scandinavica·G MUNK-ANDERSEN
May 1, 1961·The Journal of Clinical Investigation·S KOCHWAL R WASSERMAN
Apr 1, 1959·Japanese Journal of Medical Science & Biology·Y ICHIKAWA
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neil A Murray, Irene A G Roberts
Jun 1, 1961·The Journal of Experimental Medicine·G F SpringerW C Brandes
Jul 6, 2010·The Journal of Pediatrics·Michael KaplanDavid K Stevenson
Jul 16, 2015·Transfusion·Donald R Branch
Jul 26, 2018·Journal of Pediatric Hematology/oncology·Ryan A MetcalfMonica B Pagano
Jun 8, 2019·Archives of Pathology & Laboratory Medicine·Matthew S KarafinUNKNOWN College of American Pathologists Transfusion, Apheresis, and Cellular Therapy Committee
Oct 2, 2020·Journal of Pediatric Hematology/oncology·Ruyao WangNailun Su

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