From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study

Journal of Neurophysiology
Atsuko Nagano-SaitoAlain Dagher

Abstract

During simple sensorimotor decision making, neurons in the parietal cortex extract evidence from sensory information provided by visual areas until a decision is reached. Contextual information can bias parietal activity during the task and change the decision-making parameters. One type of contextual information is the availability of reward for correct decisions. We tested the hypothesis that the frontal lobes and basal ganglia use contextual information to bias decision making to maximize reward. Human volunteers underwent functional MRI while making decisions about the motion of dots on a computer monitor. On rewarded trials, subjects responded more slowly by increasing the threshold to decision. Rewarded trials were associated with activation in the ventral striatum and prefrontal cortex in the period preceding coherent dot motion, and the degree of activation predicted the increased decision threshold. Decreasing dopamine transmission, using a tyrosine-depleting amino acid mixture, abolished the reward-related corticostriatal activation and eliminated the correlation between striatal activity and decision threshold. These observations provide direct evidence that some reward-related functional MRI signals in the striatum ...Continue Reading

References

Aug 8, 1987·The Journal of Comparative Neurology·B A Vogt, D N Pandya
May 1, 1984·The Journal of Comparative Neurology·E J Mufson, D N Pandya
Sep 1, 1980·Brain : a Journal of Neurology·C Baleydier, F Mauguiere
Aug 1, 1982·Journal of Personality Assessment·M LorrS U Fisher
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D FormanD C Noll
Apr 1, 1994·Optometry and Vision Science : Official Publication of the American Academy of Optometry·G L TrickS B Steinman
Mar 1, 1994·Journal of Computer Assisted Tomography·D L CollinsA C Evans
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M N Shadlen, W T Newsome
Jul 11, 1998·Journal of Neurophysiology·W Schultz
Jul 29, 1998·Brain : a Journal of Neurology·C BüchelK J Friston
Apr 10, 1999·Nature Neuroscience·R KawagoeO Hikosaka
Jul 27, 1999·Nature·M L Platt, P W Glimcher
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LeytonC Benkelfat
Dec 9, 2000·Journal of Neurophysiology·M R DelgadoJ A Fiez
Aug 8, 2001·Psychological Review·M Usher, J L McClelland
Oct 16, 2001·Journal of Neurophysiology·M N Shadlen, W T Newsome
Oct 31, 2001·Experimental Brain Research·M WatanabeW Schultz
Jan 5, 2002·NeuroImage·K J WorsleyA C Evans
Jan 11, 2002·Journal of Neurophysiology·Yoriko TakikawaOkihide Hikosaka
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jul 26, 2002·Nature·Johan LauwereynsOkihide Hikosaka
Aug 27, 2002·Neuron·Frances S ChanceAlex D Reyes
Jan 4, 2003·Science·James W Bisley, Michael E Goldberg
Feb 13, 2003·Annals of the New York Academy of Sciences·R LlinásV I Makarenko
Feb 15, 2003·IEEE Transactions on Medical Imaging·Alex P ZijdenbosAlan C Evans
Apr 11, 2003·Nature·Paul E M PhillipsRegina M Carelli
Apr 30, 2003·Neuron·Samuel M McClureP Read Montague
Jun 20, 2003·Journal of Neurophysiology·B A J ReddiR H S Carpenter
Sep 30, 2003·The American Journal of Psychiatry·Andrew J MontgomeryPaul M Grasby
Sep 30, 2003·The Journal of Comparative Neurology·Yasushi Kobayashi, David G Amaral
Oct 30, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco LeytonChawki Benkelfat
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
Nov 6, 2004·Science·Michael J FrankRandall C O'reilly
Mar 12, 2005·Science·Philippe N ToblerWolfram Schultz
Jul 22, 2005·Cerebral Cortex·Jean-Claude DreherKaren Faith Berman
Nov 29, 2005·Science·Kazuyuki SamejimaMinoru Kimura

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Citations

Sep 3, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M BjorkDaniel W Hommer
May 6, 2014·Trends in Pharmacological Sciences·Marco Leyton, Paul Vezina
Nov 26, 2015·Nature Neuroscience·Arif A HamidJoshua D Berke
Oct 10, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sabine FrankHubert Preissl
Apr 21, 2016·Neuroscience and Biobehavioral Reviews·Liana Fattore, Marco Diana
Aug 1, 2014·Neuroscience·M J MulderB U Forstmann
Dec 3, 2013·Neuron·Adam ZaidelDora E Angelaki
Aug 27, 2013·Neuron·Long Ding, Joshua I Gold
Jul 6, 2014·Frontiers in Human Neuroscience·Max C KeukenJane Neumann
Jul 21, 2014·Psychopharmacology·Céline RamdaniThierry Hasbroucq
Jul 20, 2016·NPJ Schizophrenia·Matthias KirschnerStefan Kaiser
Jun 21, 2016·Current Biology : CB·Alessandra PeruginiMichele A Basso
Sep 23, 2014·Journal of Psychopharmacology·Atbin DjamshidianBruno B Averbeck
Feb 11, 2018·Psychopharmacology·Céline RamdaniThierry Hasbroucq
Oct 26, 2018·Cerebral Cortex·Golia ShafieiBratislav Mišic
Nov 24, 2017·Journal of Neurophysiology·Alessandra Perugini, Michele A Basso
Apr 6, 2018·Journal of Psychopharmacology·Leslie A ZebrowitzNouchine Hadjikhani
Nov 6, 2020·International Journal of Tryptophan Research : IJTR·Luca Aquili
Mar 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda EltonCharlotte A Boettiger

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