Jan 22, 2019

From Antimicrobial to Anticancer Peptides: The Transformation of Peptides

Recent Patents on Anti-cancer Drug Discovery
Yuan QinXiao F Luo

Abstract

Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positive bacteria, fungi, and tumor cells. An overview of the state of play with regard to the research trend of antimicrobial peptides in recent years and the situation of targeting tumor cells, and to make statistical analysis of the patents related to anticancer peptides published in recent years, is important both from toxicological and medical tumor therapy point of view. Based on the Science Citation Index Expanded version, the Derwent Innovation Index and Innography as data sources, the relevant literature and patents concerning antimicrobial peptides and anticancer peptides were analyzed through the Thomson Data Analyzer. Results of toxicologic and pharmacologic studies that brought to the development of patents for methods to novel tumor drugs were analyzed and sub-divided according to the specific synthesis of anticancer peptides. The literature and patent search data show that the research and development of global antimicrobial peptides and anticancer peptides has been in an incremental mo...Continue Reading

  • References62
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References

  • References62
  • Citations2

Mentioned in this Paper

Gram-Positive Bacteria
Antineoplastic Agents
Research
Neoplastic Cell
Neoplasms
Human Pharmacology Study
Bio-Informatics
Gram-Negative Bacteria
Toxic Effect
Cancer Treatment

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