From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders

Frontiers in Neuroscience
Adele RomanoSilvana Gaetani

Abstract

Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally, through the neurohypophysis, oxy is secreted into the systemic circulation to act as a hormone, thereby influencing several body functions. Oxy plays a pivotal role in parturition, milk let-down and maternal behavior and has been demonstrated to be important in the formation of pair bonding between mother and infants as well as in mating pairs. Furthermore, oxy has been proven to play a key role in the regulation of several behaviors associated with neuropsychiatric disorders, including social interactions, social memory response to social stimuli, decision-making in the context of social interactions, feeding behavior, emotional reactivity, etc. An increasing body of evidence suggests that deregulations of the oxytocinergic system might be involved in the pathophysiology of certain neuropsychiatric disorders such as autism, eating disorders, schizophrenia, mood, and anxiety disorders. The potential use of oxy in these mental health disorders is attracting growing interest sin...Continue Reading

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Citations

Aug 25, 2016·Frontiers in Neuroscience·Silvana Gaetani, Tommaso Cassano
Jan 19, 2019·Pituitary·Yuval EisenbergBrian T Layden
Apr 4, 2017·Frontiers in Cellular Neuroscience·Yoshito Mizoguchi, Akira Monji
Mar 21, 2017·European Journal of Nutrition·Roberto CoccurelloSilvana Gaetani
Jul 16, 2019·Pediatric Annals·Heather Forkey
May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adele RomanoSilvana Gaetani
Jun 5, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Linghua KongCatharina Lavebratt
Feb 1, 2021·Clinical Epigenetics·Joshua S DanoffJessica J Connelly
Apr 4, 2021·Pharmaceuticals·Luca BotticelliMaria Vittoria Micioni Di Bonaventura
Jul 28, 2021·Pediatrics·Heather ForkeyUNKNOWN COUNCIL ON FOSTER CARE, ADOPTION, AND KINSHIP CARE, COUNCIL ON COMMUNITY PEDIATRICS, COUNCIL ON CHILD ABUSE AND NEGLECT, COM

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