From autoinflammation to autoimmunity: old and recent findings

Clinical Rheumatology
Francesco CasoFabiola Atzeni

Abstract

Autoimmune diseases and autoinflammatory diseases have a number of similar etiopathogenetic and clinical characteristics, including genetic predisposition and recurrent systemic inflammatory flares. The first phase of ADs involves innate immunity: by means of TLRs, autoantigen presentation, B and T cell recruitment and autoantibody synthesis. The second phase involves adaptive immunity, a self-sustaining process in which immune complexes containing nucleic acids and autoantibodies activate self-directed inflammation. The link between autoimmunity and autoinflammation is IL-1ß, which is crucial in connecting the innate immune response due to NLR activation and the adaptive immune responses of T and B cells. In conclusion, although ADs are still considered adaptive immunity-mediated disorders, there is increasing evidence that innate immunity and inflammasomes are also involved. The aim of this review is to highlight the link between the innate and adaptive immune mechanisms involved in autoimmune diseases.

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
Jan 1, 1990·The Journal of Experimental Medicine·M ShlomchikM Weigert
Oct 4, 1996·Science·J D AltmanM M Davis
Feb 14, 1998·The Journal of Clinical Investigation·G A SchellekensW J van Venrooij
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Nov 18, 1998·Current Opinion in Oncology·G A Leget, M S Czuczman
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D BonhommeY Levy
Nov 21, 2000·The Journal of Experimental Medicine·M BattenF Mackay
Aug 4, 2001·The New England Journal of Medicine·A Davidson, B Diamond
Oct 26, 2001·Current Opinion in Immunology·B LudewigR M Zinkernagel
Apr 12, 2002·Nature·Elizabeth A LeadbetterAnn Marshak-Rothstein
Jul 3, 2002·Nature Reviews. Immunology·Ethan M Shevach
Sep 13, 2002·Immunology and Cell Biology·Petra D Cravens, Peter E Lipsky
Nov 1, 2002·Current Directions in Autoimmunity·Elizabeth A LeadbetterAnn Marshak-Rothstein
Mar 4, 2003·Nature Immunology·Adrian ListonChristopher C Goodnow
Aug 14, 2003·Molecular Immunology·B Paul Morgan, Claire L Harris
Dec 13, 2003·Immunity·Gregory A VigliantiAnn Marshak-Rothstein
Apr 13, 2004·Arthritis and Rheumatism·Allan S WiikUNKNOWN IUIS/WHO/AF/CDC Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseases
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Jun 26, 2004·International Archives of Allergy and Immunology·Alma J NautaMohamed R Daha
Dec 2, 2004·Nature Reviews. Genetics·Roger HortonStephan Beck
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Feb 5, 2005·Science·Koichi S KobayashiRichard A Flavell
Mar 9, 2005·Immunology Letters·B Paul MorganAwen M Gallimore
Jul 23, 2005·International Reviews of Immunology·Shimon Sakaguchi, Noriko Sakaguchi
Nov 2, 2005·The Journal of Experimental Medicine·Christina M LauAnn Marshak-Rothstein
Dec 13, 2005·Autoimmunity Reviews·J G M C Damoiseaux, J W Cohen Tervaert

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Citations

Feb 15, 2020·Expert Opinion on Pharmacotherapy·Francesco CasoLuisa Costa
Feb 15, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susann WinterUwe Platzbecker
Mar 10, 2020·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Sep 18, 2020·Nature Reviews. Drug Discovery·Natalie M EdnerLucy S K Walker
Sep 22, 2020·World Journal of Clinical Cases·Rossella Talotta, Erle Robertson
Dec 29, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Md Yousuf AliMd Asaduzzaman Khan
Feb 28, 2021·Clinical Rheumatology·Bingqing ZhangXue Zhang
Mar 7, 2021·Journal of Clinical Medicine·Stylianos TomarasEugen Feist
Sep 8, 2020·Burns : Journal of the International Society for Burn Injuries·Lunyang HuYu Sun
Jul 16, 2021·Frontiers in Immunology·Jie-Jie XuJun Li

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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