From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications

International Journal of Stem Cells
Sung-Hwan MoonHyung-Min Chung

Abstract

Human cardiomyocytes (CMs) cease to proliferate and remain terminally differentiated thereafter, when humans reach the mid-20s. Thus, any damages sustained by myocardium tissue are irreversible, and they require medical interventions to regain functionality. To date, new surgical procedures and drugs have been developed, albeit with limited success, to treat various heart diseases including myocardial infarction. Hence, there is a pressing need to develop more effective treatment methods to address the increasing mortality rate of the heart diseases. Functional CMs are not only an important in vitro cellular tool to model various types of heart diseases for drug development, but they are also a promising therapeutic agent for cell therapy. However, the limited proliferative capacity entails difficulties in acquiring functional CMs in the scale that is required for pathological studies and cell therapy development. Stem cells, human pluripotent stem cells (hPSCs) in particular, have been considered as an unlimited cellular source for providing functional CMs for various applications. Notable progress has already been made: the first clinical trials of hPSCs derived CMs (hPSC-CMs) for treating myocardial infarction was approved i...Continue Reading

Citations

Jul 10, 2018·Aesthetic Surgery Journal·Graeme Ewan Glass, Patrizia Ferretti
Jul 24, 2018·Experimental Dermatology·Xue LengXunwei Wu
Apr 26, 2019·Stem Cells Translational Medicine·Pooja NairIoannis Karakikes
Jan 29, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Siavash Beiranvand, Mohamad Masud Sorori
Jan 7, 2020·Experimental Dermatology·Etienne C E Wang, Claire A Higgins
Dec 19, 2018·Journal of Cardiovascular Translational Research·Shu ZhouYan Wang
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Philippe Menasché

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BETA
flow cytometry

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