DOI: 10.1101/492298Dec 10, 2018Paper

From: Benjamin Lemasson Parametric response mapping as a new MRI approach for the characterization of posttraumatic cerebral edema

BioRxiv : the Preprint Server for Biology
Jules GrezeBenjamin Lemasson

Abstract

Purpose Cerebral edema is usually assessed with mean ADC value obtained with MRI. We aimed to use parametric response mapping (PRM), a voxel-based analysis, in a rat model of traumatic brain injury (TBI) to characterize the cerebral edema and to compare findings to those obtained with the classical global mean ADC analysis. Ultimately we wished to test whether early PRM analysis could identify the vasogenic or cellular edematous pattern two hours after trauma. Materials and Methods Experiments were conducted in a rat model of TBI in accordance with French Government guidelines. Eighteen traumatic brain-injured rats (TBI group) were compared to 7 sham-operated rats (Sham group). Diffusion-weighted images were acquired before and immediately (H0), 60min (H1) and 120min (H2) after the trauma. Two regions of interest (ROI) including cortex (cortical-ROI) and the whole brain (brainROI) were manually delineated. Results Averaged ADC value in cortical-ROI was significantly reduced at H2 in the TBI group versus Sham group (715±24 vs 781±16 µm²/sec; p=0.04), not in brain-ROI (748±27 vs 801±18 µm²/sec; p=0.32). By contrast, PRM values were significantly changed in these two ROIs at as soon as H1 in the TBI group (27.5±4% of the voxels be...Continue Reading

Related Concepts

Brain
Cerebral Edema
Cerebral Cortex
Interest Groups
Magnetic Resonance Imaging
Parametritis
Placebos
Neoplasms, Post-Traumatic
Disease Management
Patterns

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.