From Berlin to London: HIV-1 Reservoir Reduction Following Stem Cell Transplantation

Current HIV/AIDS Reports
Cecilia A PratorTimothy J Henrich

Abstract

Few interventional strategies lead to significant reductions in HIV-1 reservoir size or prolonged antiretroviral (ART)-free remission. Allogeneic stem cell transplantations (SCT) with or without donor cells harboring genetic mutations preventing functional expression of CCR5, an HIV coreceptor, lead to dramatic reductions in residual HIV burden. However, the mechanisms by which SCT reduces viral reservoirs and leads to a potential functional HIV cure are not well understood. A growing number of studies involving allogeneic SCT in people with HIV are emerging, including those with and without transplants involving CCR5Δ32/Δ32 mutations. Donor cells resistant to HIV entry are likely required in order to achieve permanent ART-free viral remission. However, dramatic reductions in the HIV reservoir secondary to beneficial graft-versus-host effects may lead to loss of HIV detection in blood and various tissues and lead to prolonged time to HIV rebound in individuals with wild-type CCR5 donors. Studies of SCT recipients and those who started very early ART during hyperacute infection suggest that dramatic reductions in reservoir size or restriction of initial reservoir seeding may lead to 8-10 months of time prior to eventual, and rap...Continue Reading

References

May 4, 1973·Science·M S HirschM L Wood
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·M S HirschR S Schwartz
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M S HirschC B Carpenter
Jun 11, 1999·Medical Hypotheses·I Huzicka
Nov 5, 2005·Nature Medicine·Jeffrey J Molldrem
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katharine C HsuUNKNOWN International Histocompatibility Working Group
Apr 7, 2007·AIDS·Véronique Avettand-FenoelStéphane Blanche
May 15, 2007·Nature Genetics·Maureen P MartinMary Carrington
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric S DaarUNKNOWN Hemophilia Growth and Development Study
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sungjin KimWayne M Yokoyama
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah PalmerMartin S King
Oct 25, 2008·Seminars in Immunopathology·Jan StorekEddy Roosnek
Feb 14, 2009·The New England Journal of Medicine·Gero HütterEckhard Thiel
Mar 7, 2009·Science·Douglas D RichmanRoger J Pomerantz
Mar 25, 2009·Blood·José L Díez-MartínUNKNOWN European Group for Blood and Marrow Transplantation Lymphoma Working Party
May 11, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cecilia SimonelliPaolo De Paoli
Jun 16, 2010·Current HIV/AIDS Reports·David SerranoJuan Berenguer
Jul 20, 2010·Current Opinion in Oncology·Amrita Krishnan, Stephen J Forman
Jan 12, 2011·Annual Review of Immunology·Arman A BashirovaMary Carrington
Dec 2, 2011·The New England Journal of Medicine·John KorethRobert J Soiffer
Jan 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William J MurphyJeffrey S Miller
Apr 21, 2012·Current Opinion in Hematology·Mark BoschJan Storek
Apr 27, 2012·British Journal of Haematology·Fiona L DignanUNKNOWN British Society for Blood and Marrow Transplantation
Jun 19, 2013·Immunological Reviews·Maureen P Martin, Mary Carrington
Sep 7, 2013·Blood·John Koreth, Jerome Ritz
Oct 25, 2013·The New England Journal of Medicine·Deborah PersaudKatherine Luzuriaga
Mar 19, 2014·Frontiers in Immunology·Lorenzo MorettaMaria Cristina Mingari
Apr 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jori SymonsMonique Nijhuis
Jun 11, 2014·Blood·Gérard Socié, Jerome Ritz
Jul 23, 2014·Annals of Internal Medicine·Timothy J HenrichDaniel R Kuritzkes

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Citations

Jan 28, 2021·Microorganisms·Jean-François BruxelleRalph Pantophlet

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