From biomarker strategies to biomarker activities and back

Drug Discovery Today
Alain J van GoolErik D Sprengers

Abstract

The pharmaceutical industry must find ways to improve the unacceptably high attrition rate during drug development. Clearly, pharma has moved away from treat-and-see testing of new drugs in patients, with a strong current focus on generating translational biomarkers early in the research process to enable more predictive evaluation of drug action in clinical trials. Underlying such a translational medicine approach is the intensive search for and use of high-quality biomarkers indicative of successful drug target engagement, pharmacological effects, efficacy or safety. This review outlines our rational question-based drug development strategy in which biomarker data drive decisions on which drug candidates to progress to clinical testing.

Citations

Nov 20, 2012·Bioanalysis·Ruth M Barnard
Apr 3, 2012·Expert Review of Proteomics·Alain J van Gool, Ronald C Hendrickson
Oct 16, 2012·Analytica Chimica Acta·Agnieszka SmolinskaSybren S Wijmenga
Oct 22, 2011·Drug Discovery Today·Rocco Savino, Rosa Terracciano
Aug 1, 2015·The British Journal of Nutrition·Anne M MinihanePhilip C Calder
Dec 27, 2017·Pediatric Research·Lauren E KellyThomas Diacovo
Mar 29, 2018·Journal of Neurotrauma·Mohammad Mehdi BanoeiBrent W Winston
Nov 24, 2018·Expert Review of Proteomics·Roel TansAlain J van Gool
May 20, 2020·Expert Review of Proteomics·Alain Van GoolMarei Sammar
Nov 3, 2020·Journal of Separation Science·Shannon L ThomasKatarína Maráková
Dec 22, 2020·Thérapie·Mathieu CharvériatLuc Zimmer

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