From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

Nature Reviews. Drug Discovery
William A Banks

Abstract

One of the biggest challenges in the development of therapeutics for central nervous system (CNS) disorders is achieving sufficient blood-brain barrier (BBB) penetration. Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease. This complexity confounds simple strategies for drug delivery to the CNS, but provides a wealth of opportunities and approaches for drug development. Here, I review some of the most important areas that have recently redefined the BBB and discuss how they can be applied to the development of CNS therapeutics.

References

Jan 1, 1990·Behavioural Brain Research·C G EllardC H Vanderwolf
Sep 1, 1985·Brain Research Bulletin·W A Banks, A J Kastin
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M WahlL Schilling
Jan 1, 1986·Annual Review of Biochemistry·I MellmanA Helenius
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R N KalariaS I Harik
Nov 1, 1985·Acta Physiologica Scandinavica·J E Hardebo, J Kåhrström
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·W H Oldendorf
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Sep 1, 1982·The American Journal of Physiology·E M CornfordM A Hill
Oct 1, 1996·Journal of Neurochemistry·N DrionJ M Scherrmann
Mar 1, 1996·Brain Research. Molecular Brain Research·J F Poduslo, G L Curran
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Wolfgang Löscher, Heidrun Potschka
Apr 20, 2002·Journal of Neuroendocrinology·B KisY Ueta
Sep 28, 2002·Diabetes·Hans-Peter HammesUrban Deutsch
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J M StarrI Marshall

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Citations

Apr 5, 2016·Chemical Communications : Chem Comm·Elena M Sánchez-FernándezCarmen Ortiz Mellet
Sep 7, 2016·International Journal of Molecular Sciences·Thomas C ChenAxel H Schönthal
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Keisuke YanagidaTimothy Hla
Dec 6, 2016·Pharmacology & Therapeutics·David Ferland-McColloughGiuseppe Mangialardi
Dec 14, 2016·Pflügers Archiv : European journal of physiology·A K Reinhold, H L Rittner
Feb 18, 2017·Current Opinion in Hematology·Maria Grazia LampugnaniNoemi Rudini
Dec 7, 2016·Biochemical and Biophysical Research Communications·Mariko KurodaToshihide Yamashita
Jan 17, 2017·Nature Reviews. Microbiology·Mathieu CoureuilXavier Nassif
Jan 31, 2017·Neurobiology of Disease·Leo Otsuki, Andrea H Brand
Mar 25, 2017·Biochemical and Biophysical Research Communications·Yasuhiro KokubuKenji Kawabata
Jun 27, 2017·Advanced Drug Delivery Reviews·Vasileios AskoxylakisRakesh K Jain
Feb 23, 2018·Expert Opinion on Drug Delivery·Zahraa S Al-Ahmady
Mar 6, 2018·Current Psychiatry Reports·Alexander C Conley, Paul A Newhouse
Mar 21, 2018·SLAS Discovery·Stefan Bröer
Dec 1, 2017·International Journal of Molecular Sciences·Juwina WijayaJohn D Schuetz
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Botond PenkeLívia Fülöp
Feb 10, 2018·Materials·Rémy PoupotSéverine Fruchon
Feb 27, 2018·Chemical Society Reviews·Christopher D SpicerMolly M Stevens
May 23, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wenlu LiXiaoying Wang
Nov 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William A BanksYoichi Morofuji
Mar 17, 2017·Scientific Reports·Ramesh RaliyaPratim Biswas
Jul 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kae Sato, Kiichi Sato
Apr 28, 2016·CNS Drugs·Edward Lewis Tobinick
Apr 14, 2018·Integrative Cancer Therapies·Tao WuQiaoyuan Cheng
Aug 31, 2017·Cold Spring Harbor Perspectives in Biology·Maria Grazia LampugnaniCostanza Giampietro
Oct 4, 2018·Physiological Reviews·Melanie D SweeneyBerislav V Zlokovic
Feb 6, 2018·Scientific Reports·Yi KungWen-Shiang Chen
Mar 14, 2018·Scientific Reports·Hiroya KuwaharaTakanori Yokota
Apr 13, 2019·Neuropathology and Applied Neurobiology·L BerteroP Cassoni
Oct 9, 2018·Journal of Drug Targeting·Shoshy MizrahyDan Peer
Jan 20, 2018·Nature Reviews. Neuroscience·Michael J Devine, Josef T Kittler
May 31, 2019·Current Protocols in Pharmacology·Joanna HummerThomas Birngruber
May 16, 2019·Chemical Society Reviews·Wei TangXiaoyuan Chen

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