From cell to heart: the impact of the cell organelles dysfunction on heart disease

Journal of Cardiovascular Medicine
Angelos TsipisGeorge Athanassopoulos

Abstract

: Cellular morphology reflects biologic behavior and activity of the tissue and of the organ also reflects the genetic and molecular biology of the cells themselves. This intermediary position places examination of the cell in a key role to our understanding of the innumerable processes that affect this closely knit chain, from molecules to host. A large volume of the cell is occupied by organelles that come in a variety of shapes and sizes. Organelles are dynamic to maintain homeostasis and adjust to the various functions of the cell. The cardiovascular system is metabolically very active and is therefore particularly vulnerable to defects of the cellular substructures, such as the mitochondrial respiratory chain. Given the functional complexity of the cardiovascular system, it is not surprising that defects in cell organelles produce diverse clinical manifestations. Organelle dysfunction is being recognized as the basis of a wide variety of heart diseases. In this review, the authors discuss the relationship between organelle structure and function in myocardial cells and how these organelles have been linked to the cardiovascular diseases.

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Mar 1, 1995·Journal of Molecular and Cellular Cardiology·A M Gerdes, J M Capasso
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·C A BeltramiP Anversa
Oct 1, 1994·Current Opinion in Cell Biology·P J Koch, W W Franke
Jul 1, 1994·Physiological Reviews·T PozzanJ Meldolesi
Jun 20, 1998·Circulation Research·P Anversa, J Kajstura
Mar 12, 1999·Annual Review of Medicine·D K Simon, D R Johns
Mar 23, 2000·Cardiovascular Research·S HeinJ Schaper
Dec 7, 2000·The New England Journal of Medicine·M KamisagoC E Seidman
Apr 12, 2001·International Journal of Experimental Pathology·B GuertlG Hoefler
Jun 9, 2001·Circulation Research·R S Ross, T K Borg
Jan 30, 2002·Circulation·Hideshi NiimuraChristine E Seidman
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jörg StypmannThomas Reinheckel
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Gerd Hasenfuss, Burkert Pieske
Oct 11, 2002·Cardiovascular Drugs and Therapy·Arnold M Katz
Nov 6, 2002·Genetic Engineering·Shaw-Yung ShaiRobert S Ross
Dec 3, 2002·Revista española de cardiología·José Marín-García, Michael J Goldenthal
Jan 30, 2003·Journal of Cardiac Failure·A Martin Gerdes
May 17, 2003·The Journal of Clinical Investigation·Detlef WenckerRichard N Kitsis
Sep 23, 2003·Circulation Research·Donald M BersHector H Valdivia
Dec 9, 2003·The Journal of Physiology·Renée Ventura-ClapierVladimir Veksler
Feb 28, 2004·Expert Reviews in Molecular Medicine·Josephine S Modica-Napolitano, Keshav K Singh
May 1, 2004·Circulation Research·Karen A LapidosElizabeth M McNally
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rajanya D ShahHuda E Shubeita
Sep 27, 2005·Physiological Reviews·Jeanne M Nerbonne, Robert S Kass
Oct 10, 2006·Journal of Molecular and Cellular Cardiology·Chun-Hong ShaoKeshore R Bidasee
Nov 10, 2007·Circulation Research·Christopher C Glembotski
Feb 29, 2008·BMB Reports·Seon-Yong Jeong, Dai-Wu Seol
Nov 20, 2008·Journal of Clinical Pathology·A LukJ Butany
Mar 30, 2010·Heart Failure Clinics·Diane FatkinZara Richmond
Mar 30, 2010·Heart Failure Clinics·Carolyn Y Ho
May 27, 2010·European Journal of Clinical Investigation·Ali J Marian
Jul 2, 2010·Pathology, Research and Practice·Angelos TsipisEfstratios Patsouris
Sep 28, 2010·Biochimica Et Biophysica Acta·Renée Ventura-ClapierFrédéric Joubert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2022 Meta ULC. All rights reserved