PMID: 18196975Jan 17, 2008Paper

From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages

Cell Cycle
Ana Rodrigues-MartinsMónica Bettencourt-Dias

Abstract

Centrioles are essential for the formation of cilia, flagella and centrosome organization. Abnormalities in centrosome structure and number in many cancers can be associated with aberrant cell division and genomic instability.(1,2) Canonical centriole duplication occurs in coordination with the cell division cycle, such that a single new "daughter" centriole arises next to each "mother" centriole. If destroyed, or eliminated during development, centrioles can form de novo.(3-5) Here we discuss our recent data demonstrating a molecular pathway that operates in both de novo and canonical centriole biogenesis involving SAK/PLK4, SAS-6 and SAS-4.(6) We showed that centriole biogenesis is a self-assembly process locally triggered by high SAK/PLK4 activity that may or not be associated with an existing centriole. SAS-6 acts downstream of SAK/PLK4 to organize nine precentriolar units, which we call here enatosomes, fitting together laterally and longitudinally, specifying a tube-like centriole precursor.(7,8) The identification of mutants impaired in centriole biogenesis has permitted the study of the physiological consequences of their absence in the whole organism. In Drosophila, centrioles are not necessary for somatic cell divisio...Continue Reading

Citations

Mar 20, 2010·Cellular and Molecular Life Sciences : CMLS·Alain DebecMonica Bettencourt-Dias
Jan 20, 2010·The Journal of Biological Chemistry·Jayachandran GopalakrishnanTomer Avidor-Reiss
Mar 27, 2009·Molecular Biology of the Cell·Violaine Mottier-Pavie, Timothy L Megraw
Apr 10, 2009·Molecular Biology of the Cell·Michael A AndersonLaura A Lee
Jan 10, 2012·Science·Juliette AzimzadehWallace F Marshall
May 21, 2013·Eukaryotic Cell·Jessica Cruz de LeonNaomi S Morrissette
Apr 13, 2013·BMC Biology·Mónica Bettencourt-Dias
Jan 2, 2013·Journal of Cell Science·Nan Tang, Wallace F Marshall
Nov 21, 2008·PloS One·Hugh R Woodland, Andrew M Fry
Dec 15, 2015·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Dorothy A Lerit, John S Poulton
Nov 10, 2010·The Journal of Cell Biology·Emily M HatchTim Stearns
Aug 2, 2012·The Journal of Cell Biology·Aurélien CourtoisTakashi Hiiragi
Apr 18, 2012·The Journal of Cell Biology·Camille EnjolrasBénédicte Durand
Jun 20, 2012·The Journal of Cell Biology·Ivo A TelleyThomas Surrey
Jul 27, 2011·The Journal of Cell Biology·Zita Carvalho-SantosMónica Bettencourt-Dias
Oct 21, 2015·Developmental Cell·Carla A M LopesMónica Bettencourt-Dias
Jun 18, 2011·Trends in Genetics : TIG·Mónica Bettencourt-DiasSusana A Godinho
Feb 5, 2009·Traffic·Chad G Pearson, Mark Winey
May 7, 2009·Traffic·Inês Cunha-FerreiraMónica Bettencourt-Dias
Mar 24, 2009·Cell Motility and the Cytoskeleton·Maria Giovanna RiparbelliRomano Dallai
Jun 12, 2010·Cytoskeleton·Lani C KellerWallace F Marshall
Dec 9, 2014·Cell Cycle·Ahuvit DavidAlwin Krämer
Mar 18, 2015·Journal of Evolutionary Biology·L Ross, B B Normark
Nov 5, 2013·Current Biology : CB·Inês Cunha-FerreiraMónica Bettencourt-Dias
Nov 5, 2013·Current Biology : CB·Joseph E KlebbaGregory C Rogers
Nov 11, 2008·Current Opinion in Cell Biology·Cayetano Gonzalez
Dec 17, 2008·Current Biology : CB·Inês Cunha-FerreiraMónica Bettencourt-Dias
Oct 24, 2009·Trends in Genetics : TIG·Gemma K Thornton, C Geoffrey Woods
Dec 30, 2017·The Journal of Cell Biology·Jadranka Loncarek, Mónica Bettencourt-Dias
Jun 4, 2019·Chromosoma·Alberto Pineda-Santaella, Alfonso Fernández-Álvarez
Mar 4, 2018·The Journal of Cell Biology·Mustafa G AydoganJordan W Raff
Sep 22, 2020·Current Opinion in Structural Biology·Shohei Yamamoto, Daiju Kitagawa
Mar 25, 2021·The Journal of Cell Biology·Catarina NabaisMónica Bettencourt-Dias
Oct 27, 2010·Developmental Biology·Maria Giovanna Riparbelli, Giuliano Callaini

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