From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity

Frontiers in Pharmacology
Guido GambaraAlessandra Silvestri

Abstract

Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different facets of ITH, from genomic to microenvironmental heterogeneity and the hierarchical cellular architecture originating from the cancer stem cell compartment, contribute to the range of tumor phenotypes. Decoding these complex data resulting from the analysis of tumor tissue complexity poses a challenge for developing novel therapeutic strategies that can counteract tumor evolution and cellular plasticity. To achieve this aim, the development of in vitro and in vivo cancer models that resemble the complexity of ITH is crucial in understanding the interplay of cells and their (micro)environment and, consequently, in testing the efficacy of new targeted treatments and novel strategies of tailoring combinations of treatments to the individual composition of the tumor. This challenging approach may be an important cornerstone in overcoming the development of pharmaco-resistances during multiple lines of treatment. In this paper, we report the latest advances in patient-derived 3D (PD3D) cell cultures and patient-der...Continue Reading

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Citations

Jan 25, 2019·NPJ Precision Oncology·Sara E PattersonSusan M Mockus
Oct 16, 2018·Frontiers in Immunology·Aifen Lin, Wei-Hua Yan
Nov 28, 2020·Trends in Cancer·Bruce GottliebGerald Batist

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Methods Mentioned

BETA
biopsy
xenografts
xenograft
biopsies
exome

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