From clock to functional pacemaker.

The European Journal of Neuroscience
Stephan Michel, Johanna H Meijer

Abstract

In mammals, the central pacemaker that coordinates 24-hr rhythms is located in the suprachiasmatic nucleus (SCN). Individual neurons of the SCN have a molecular basis for rhythm generation and hence, they function as cell autonomous oscillators. Communication and synchronization among these neurons are crucial for obtaining a coherent rhythm at the population level, that can serve as a pace making signal for brain and body. Hence, the ability of single SCN neurons to produce circadian rhythms is equally important as the ability of these neurons to synchronize one another, to obtain a bona fide pacemaker at the SCN tissue level. In this chapter we will discuss the mechanisms underlying synchronization, and plasticity herein, which allows adaptation to changes in day length. Furthermore, we will discuss deterioration in synchronization among SCN neurons in aging, and gain in synchronization by voluntary physical activity or exercise.

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Citations

Apr 28, 2019·International Journal of Molecular Sciences·Lama El Cheikh HusseinXavier Bonnefont
Dec 10, 2019·The European Journal of Neuroscience·Karen L Gamble, Rae Silver
Aug 28, 2020·Reviews in the Neurosciences·Dorothea DereEkrem Dere
Dec 29, 2020·Journal of Neurochemistry·M Renate Buijink, Stephan Michel
Jul 13, 2021·Frontiers in Physiology·Elizabeth A SchroderBrian P Delisle

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