From CNTNAP2 to Early Expressive Language in Infancy: The Mediation Role of Rapid Auditory Processing

Cerebral Cortex
Valentina RivaCecilia Marino

Abstract

Although it is clear that early language acquisition can be a target of CNTNAP2, the pathway between gene and language is still largely unknown. This research focused on the mediation role of rapid auditory processing (RAP). We tested RAP at 6 months of age by the use of event-related potentials, as a mediator between common variants of the CNTNAP2 gene (rs7794745 and rs2710102) and 20-month-old language outcome in a prospective longitudinal study of 96 Italian infants. The mediation model examines the hypothesis that language outcome is explained by a sequence of effects involving RAP and CNTNAP2. The ability to discriminate spectrotemporally complex auditory frequency changes at 6 months of age mediates the contribution of rs2710102 to expressive vocabulary at 20 months. The indirect effect revealed that rs2710102 C/C was associated with lower P3 amplitude in the right hemisphere, which, in turn, predicted poorer expressive vocabulary at 20 months of age. These findings add to a growing body of literature implicating RAP as a viable marker in genetic studies of language development. The results demonstrate a potential developmental cascade of effects, whereby CNTNAP2 drives RAP functioning that, in turn, contributes to early ...Continue Reading

References

Feb 1, 1990·Journal of Child Language·B A Goldfield, J S Reznick
Jun 1, 1980·Journal of Pediatric Psychology·P Tallal
Jun 14, 1993·Annals of the New York Academy of Sciences·A A Benasich, P Tallal
Jun 1, 1997·Journal of Personality Assessment·S L Crowley, X Fan
Apr 9, 1999·Nature Neuroscience·P S DaleR Plomin
Apr 28, 2001·Journal of Speech, Language, and Hearing Research : JSLHR·L Rescorla, A Alley
Oct 19, 2002·Behavioural Brain Research·April A Benasich, Paula Tallal
Sep 10, 2003·The Journal of Cell Biology·Sebastian PoliakElior Peles
Feb 6, 2004·Brain Research. Developmental Brain Research·Ann M PeifferR Holly Fitch
Apr 9, 2005·Journal of Learning Disabilities·Jacqueline LiedermanKathleen Flannery
May 6, 2005·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tomi K GuttormHeikki Lyytinen
Jun 30, 2006·Trends in Neurosciences·Paula Tallal, Nadine Gaab
Apr 21, 2007·Psychological Science·Matthew S Fritz, David P Mackinnon
Nov 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·B S AbrahamsD H Geschwind
Jan 9, 2008·American Journal of Human Genetics·Maricela AlarcónDaniel H Geschwind
Nov 7, 2008·The New England Journal of Medicine·Sonja C VernesSimon E Fisher
Dec 17, 2008·Annals of the New York Academy of Sciences·Vasiliki FoliaKarl Magnus Petersson
Feb 17, 2010·Current Directions in Psychological Science·David P Mackinnon, Amanda J Fairchild
Jan 1, 2004·Multivariate Behavioral Research·David P MackinnonJason Williams
Jan 1, 2008·Structural Equation Modeling : a Multidisciplinary Journal·Jason Williams, David P Mackinnon
Jul 3, 2010·International Journal of Oncology·Remco M Van den BergPeter J F Snijders
Jul 27, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Paavo H T LeppänenHeikki Lyytinen
Aug 6, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Naseem Choudhury, April A Benasich
Oct 23, 2010·Journal of Speech, Language, and Hearing Research : JSLHR·Jens HenrichsHenning Tiemeier
Feb 12, 2011·Genes, Brain, and Behavior·A J O WhitehouseS E Fisher
Apr 14, 2011·Behavior Research Methods·Davood Tofighi, David P MacKinnon
Oct 12, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Heather C WhalleyJeremy Hall
Dec 14, 2011·Neuroscience and Biobehavioral Reviews·K O'Connor
Mar 1, 2012·Trends in Molecular Medicine·Olga Peñagarikano, Daniel H Geschwind
May 30, 2013·European Journal of Human Genetics : EJHG·Pedro Rodenas-CuadradoSonja C Vernes
Jan 15, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rafał MilnerHenryk Skarżyński
May 2, 2014·Frontiers in Human Neuroscience·Javier Lopez-Calderon, Steven J Luck
May 16, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Leslie RescorlaEmiddia Longobardi
Oct 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·April A BenasichCynthia P Roesler
Oct 27, 2015·Behavioral Neuroscience·Dongnhu T TruongR Holly Fitch
Feb 18, 2016·European Journal of Human Genetics : EJHG·Carmen C BrewerDavid R Moore

❮ Previous
Next ❯

Citations

Dec 18, 2019·Language and Linguistics Compass·Nicole Landi, Meaghan Perdue
Sep 8, 2021·Frontiers in Integrative Neuroscience·Dorit MöhrleSusanne Schmid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.