From COVID-19 research to vaccine application: why might it take 17 months not 17 years and what are the wider lessons?

Health Research Policy and Systems
Stephen R HanneyJonathan Grant

Abstract

It is often said that it takes 17 years to move medical research from bench to bedside. In a coronavirus disease (COVID-19) world, such time-lags feel intolerable. In these extraordinary circumstances could years be made into months? If so, could those lessons be used to accelerate medical research when the crisis eases?To measure time-lags in health and biomedical research as well as to identify ways of reducing them, we developed and published (in 2015) a matrix consisting of overlapping tracks (or stages/phases) in the translation from discovery research to developed products, policies and practice. The matrix aids analysis by highlighting the time and actions required to develop research (and its translation) both (1) along each track and (2) from one track to another, e.g. from the discovery track to the research-in-humans track. We noted four main approaches to reducing time-lags, namely increasing resources, working in parallel, starting or working at risk, and improving processes.Examining these approaches alongside the matrix helps interpret the enormous global effort to develop a vaccine for the 2019 novel coronavirus SARS-CoV-2, the causative agent of COVID-19. Rapid progress in the discovery/basic and human research...Continue Reading

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Citations

Sep 30, 2020·Human Vaccines & Immunotherapeutics·Harapan HarapanMudatsir Mudatsir
Jun 24, 2020·Health Research Policy and Systems·Stephen R HanneyAnnette Boaz
Aug 23, 2020·Biology·Irina KiselevaLarisa Rudenko
Sep 19, 2020·Health Research Policy and Systems·Jason H PitzenGregory J Gores
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Adriana PeroDongming Cai
Dec 5, 2020·British Journal of Community Nursing·Alison Phillis
Jan 5, 2021·Annals of Medicine and Surgery·Michelle GriffinRiaz Agha
Feb 5, 2021·British Journal of Community Nursing·Alison Phillis
Feb 5, 2021·Clinical Trials : Journal of the Society for Clinical Trials·Haley HedlinManisha Desai
Dec 20, 2020·Health Research Policy and Systems·Bahareh YazdizadehBita Mesgarpour
Mar 25, 2021·Journal of Integrative Bioinformatics·Anusha UttarilliAbhishek Kumar
Jun 12, 2021·Royal Society Open Science·Mahendra PiraveenanMatjaz Perc
Aug 20, 2021·Health Research Policy and Systems·Sana ZakariaJane Luff
Aug 29, 2021·International Immunopharmacology·Kiana ShahzamaniShaghayegh Haghjooy Javanmard
Sep 11, 2021·Expert Opinion on Drug Discovery·Andreas H LaustsenAnne Ljungars

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Methods Mentioned

BETA
cognitive behavioural therapy

Software Mentioned

Moderna
CanSino
OpenIP

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