From Default Mode Network to the Basal Configuration: Sex Differences in the Resting-State Brain Connectivity as a Function of Age and Their Clinical Correlates

Frontiers in Psychiatry
Sean D ConrinAlex Leow

Abstract

Connectomics is a framework that models brain structure and function interconnectivity as a network, rather than narrowly focusing on select regions-of-interest. MRI-derived connectomes can be structural, usually based on diffusion-weighted MR imaging, or functional, usually formed by examining fMRI blood-oxygen-level-dependent (BOLD) signal correlations. Recently, we developed a novel method for assessing the hierarchical modularity of functional brain networks-the probability associated community estimation (PACE). PACE uniquely permits a dual formulation, thus yielding equivalent connectome modular structure regardless of whether positive or negative edges are considered. This method was rigorously validated using the 1,000 functional connectomes project data set (F1000, RRID:SCR_005361) (1) and the Human Connectome Project (HCP, RRID:SCR_006942) (2, 3) and we reported novel sex differences in resting-state connectivity not previously reported. (4) This study further examines sex differences in regard to hierarchical modularity as a function of age and clinical correlates, with findings supporting a basal configuration framework as a more nuanced and dynamic way of conceptualizing the resting-state connectome that is modulat...Continue Reading

References

Dec 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·M Piccinelli, G Wilkinson
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
May 15, 2001·International Clinical Psychopharmacology·J Wålinder, W Rutzt
Aug 9, 2002·Journal of Cognitive Neuroscience·W M KelleyT F Heatherton
Nov 5, 2003·The American Journal of Psychiatry·Philippe FossatiHelen Mayberg
Mar 30, 2004·CNS Spectrums·K Luan PhanIsrael Liberzon
May 4, 2005·Trends in Cognitive Sciences·Kevin N Ochsner, James J Gross
Dec 6, 2005·NeuroImage·Taylor W Schmitz, Sterling C Johnson
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Santo Fortunato, Marc Barthélemy
Jun 25, 2008·Social Cognitive and Affective Neuroscience·Marcia K JohnsonSusan Nolen-Hoeksema
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Dec 18, 2009·Neuroscience and Biobehavioral Reviews·Lisette van der MeerAnthony S David
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Roger Guimerà, Marta Sales-Pardo
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Dec 15, 2010·Frontiers in Neuroscience·David MeunierEdward T Bullmore
May 21, 2011·Psychiatry Research·Ariel Beth BrownLarry Seidman
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine Lebel, Christian Beaulieu
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
Jan 5, 2013·Medical Image Computing and Computer-assisted Intervention : MICCAI·Johnson J GadElkarimAlex D Leow
May 7, 2013·NeuroImage·Alex FornitoMichael Breakspear
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
Oct 15, 2013·Frontiers in Human Neuroscience·Ayna Baladi NejadCédric Lemogne
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Madhura IngalhalikarRagini Verma
Apr 16, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Abeer Abu-ZeitoneArthur J Moss
Aug 15, 2014·Journal of Clinical and Diagnostic Research : JCDR·Namrata Upadhayay, Sanjeev Guragain
Aug 22, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brenton W McMenaminLuiz Pessoa
Dec 19, 2014·Biology of Sex Differences·Marianne L Seney, Etienne Sibille
Feb 18, 2015·Social Cognitive and Affective Neuroscience·Nicole Petersen, Larry Cahill
Sep 24, 2015·Annual Review of Psychology·Olaf Sporns, Richard F Betzel
Sep 26, 2015·Psychoneuroendocrinology·Jonas EngmanMohammed R Milad
Nov 22, 2016·Journal of Neuroscience Research·Tracey J ShorsBrandon L Alderman
Jul 5, 2017·The Journal of Comparative Neurology·Liang ZhanAlex D Leow
Oct 28, 2017·Scientific Reports·Johannes HertelHans Joergen Grabe
Apr 16, 2018·Journal of Affective Disorders·Gennady G KnyazevLyubomir I Aftanas

❮ Previous
Next ❯

Citations

Oct 22, 2019·The European Journal of Neuroscience·Harriet L L Day, Carl W Stevenson
Dec 7, 2018·Frontiers in Psychology·Shervin AssariMarc A Zimmerman
Dec 17, 2020·Magnetic Resonance Imaging·Ravi Bansal, Bradley S Peterson

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Key Resources (RRID) Mentioned

SCR_005361
SCR_006942

Software Mentioned

PACE

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.