From design to the clinic: practical guidelines for translating cardiovascular nanomedicine.

Cardiovascular Research
Iwona CichaDidier Letourneur

Abstract

Cardiovascular diseases (CVD) account for nearly half of all deaths in Europe and almost 30% of global deaths. Despite the improved clinical management, cardiovascular mortality is predicted to rise in the next decades due to the increasing impact of aging, obesity, and diabetes. The goal of emerging cardiovascular nanomedicine is to reduce the burden of CVD using nanoscale medical products and devices. However, the development of novel multicomponent nano-sized products poses multiple technical, ethical, and regulatory challenges, which often obstruct their road to successful approval and use in clinical practice. This review discusses the rational design of nanoparticles, including safety considerations and regulatory issues, and highlights the steps needed to achieve efficient clinical translation of promising nanomedicinal products for cardiovascular applications.

References

Jul 11, 2000·Pharmaceutical Research·S DokkaY Rojanasakul
Sep 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Galina K SukhovaPeter Libby
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Rikin A TrivediJonathan H Gillard
Dec 22, 2007·Nanomedicine·Jennifer B HallScott E McNeil
Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tjun Y TangJ H Gillard
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan F GranadaErling Falk
Dec 4, 2009·Biomaterials·Phapanin CharoenpholOmolola Eniola-Adefeso
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Scott E McNeil
Jan 12, 2010·Journal of Internal Medicine·G Oberdörster
Apr 15, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·S M MoghimiJ Szebeni
Aug 5, 2010·Current Opinion in Lipidology·Jacob Fog Bentzon, Erling Falk
Feb 5, 2011·Current Drug Discovery Technologies·Rainer H MüllerCornelia M Keck
Feb 10, 2011·Circulation. Cardiovascular Imaging·Jennifer M J RichardsDavid E Newby
Jan 24, 2012·International Journal of Nanomedicine·Massimo BottiniAndrea Magrini
Mar 13, 2012·The AAPS Journal·Neil Desai
Mar 13, 2012·Archives of Toxicology·Alexandra KrollJürgen Schnekenburger
Jun 12, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Michael L EtheridgeJeffrey McCullough
Jul 10, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Rachael M CristScott E McNeil
Jul 24, 2012·Advanced Drug Delivery Reviews·János SzebeniRudolf Urbanics
Jul 31, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Umar SadatJonathan H Gillard
Dec 4, 2012·Regulatory Toxicology and Pharmacology : RTP·Eric A J BleekerAgnes G Oomen
Dec 12, 2012·Advanced Drug Delivery Reviews·Lin MeiSi-Shen Feng
Dec 15, 2012·Biomaterials·Johannes RieglerMark F Lythgoe
Mar 16, 2013·Annals of Neurology·Dong-Eog KimKwangmeyung Kim
May 2, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ana Lilia Barrán-BerdónAldo Laganà
Jun 4, 2013·Biological & Pharmaceutical Bulletin·Tatsuhiro Ishida, Hiroshi Kiwada
Sep 28, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Juliette MérianBertrand Tavitian
Dec 24, 2013·Nanomedicine·Marina A DobrovolskaiaScott E McNeil

❮ Previous
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Citations

Apr 1, 2019·European Heart Journal·Pasquale Maffia, Tomasz J Guzik
Aug 29, 2019·Nanomedicine·Michele IafiscoDaniele Catalucci
Feb 6, 2020·Immunology·Simon D HardingJamie A Davies
May 28, 2020·Antioxidants & Redox Signaling·Henry W West, Charalambos Antoniades
Jul 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandor I BernadElena S Bernad
Jun 18, 2020·International Journal of Nanomedicine·Rajasekharreddy PalaSurya M Nauli
Mar 7, 2020·Drug Delivery and Translational Research·João Pedro MartinsHélder A Santos
Oct 13, 2020·Nanotechnology·Paolo DecuzziTwan Lammers
Jan 16, 2021·International Journal of Nanomedicine·Fahad AlbalawiMas Jaffri Masarudin
Feb 2, 2021·International Journal of Pharmaceutics·C ReboredoJ M Irache
Mar 5, 2021·Drug Delivery and Translational Research·Margarida Ferreira-SilvaMaria Luísa Corvo
May 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luciana P TavaresFrancesca Levi-Schaffer
Aug 21, 2020·Biomaterials·Alina ZenychCédric Chauvierre
Apr 17, 2021·ACS Pharmacology & Translational Science·Nahid S AwadGhaleb A Husseini
Jan 27, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Jonathan VigneIsabelle Texier
Jun 27, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Reshma Vasantha RamachandranAmbarish Ghosh
Aug 12, 2021·British Journal of Pharmacology·Neil MacRitchiePasquale Maffia

❮ Previous
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