From Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and disease.

Journal of Neurogenetics
Paulo A Ferreira, Andrew Orry

Abstract

Despite remarkable advances in human genetics and other genetic model systems, the fruit fly, Drosophila melanogaster, remains a powerful experimental tool to probe with ease the inner workings of a myriad of biological and pathological processes, even when evolutionary forces impart apparent divergences to some of such processes. The understanding of such evolutionary differences provides mechanistic insights into genotype-phenotype correlations underpinning biological processes across metazoans. The pioneering work developed by the William Pak laboratory for the past four decades, and the work of others, epitomize the notion of how the Drosophila system breaks new fertile ground or complements research fields of high scientific and medical relevance. Among the three major genetic complementation groups produced by the Pak's laboratory and impairing distinct facets of photoreceptor neuronal function, the nina group (ninaA, …., ninaJ) selectively affects the biogenesis of G protein-coupled receptors (GPCRs), mediating the photoconversion and transduction of light stimuli. Among the nina genes identified, ninaA arguably assumes heightened significance for several reasons. First, it presents unique physiological selectivity towar...Continue Reading

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Citations

Jul 18, 2014·PLoS Genetics·Ville-Petteri MäkinenThemistocles L Assimes
Mar 22, 2014·Proceedings. Biological Sciences·Christoph Effertz, Eric von Elert
Jan 2, 2014·Journal of Molecular and Cellular Cardiology·Marco Sandri, Jeffrey Robbins
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Sep 8, 2012·Journal of Medicinal Chemistry·Alexander N WeinMichael Peredelchuk
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Nov 23, 2013·Communicative & Integrative Biology·Dipesh Kumar TrivediNarendra Tuteja
Mar 25, 2019·Nature Chemistry·Mikail E AbbasovDaniel Romo

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