From drug delivery systems to drug release, dissolution, IVIVC, BCS, BDDCS, bioequivalence and biowaivers.

Pharmaceutical Research
Vangelis KaralisPanos Macheras

Abstract

This is a summary report of the conference on drug absorption and bioequivalence issues held in Titania Hotel in Athens (Greece) from the 28(th) to the 30(th) of May 2009. The conference included presentations which were mainly divided into three sections. The first section focused on modern drug delivery systems such as polymer nanotechnology, cell immobilization techniques to deliver drugs into the brain, nanosized liposomes used in drug eluting stents, encapsulation of drug implants in biocompatible polymers, and application of differential scanning calorimetry as a tool to study liposomal stability. The importance of drug release and dissolution were also discussed by placing special emphasis on camptothecins and oral prolonged release formulations. The complexity of the luminal environment and the value of dissolution in lyophilized products were also highlighted. The second session of the conference included presentations on the Biopharmaceutics Classification Scheme (BCS), the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the role of transporters in the classification of drugs. The current status of biowaivers and a modern view on non-linear in vitro-in vivo (IVIVC) correlations were also addressed...Continue Reading

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Citations

Jul 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lacramioara OchiuzAnca Giorgiana Grigoras
Aug 10, 2020·Drug Development Research·Vignesh Mohan, Khushwant S Yadav
Jun 8, 2021·Frontiers in Pharmacology·Constantin MircioiuVictor A Voicu

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