From Dyestuff Chemistry to Cancer Theranostics: The Rise of Rylenecarboximides

Accounts of Chemical Research
Chendong JiMeizhen Yin

Abstract

Fighting cancer with the means of chemistry remains a tremendous challenge and defines a pressing societal need. Compounds based on synthetic organic dyes have long been recognized as vital tools for cancer diagnosis and therapy (theranostics). Fluorescence and photoacoustic imaging of cancer as well as cancer treatment protocols such as photodynamic and photothermal therapy are all photobased technologies that require chromophores. However, a serious drawback of most chromophoric molecules is photobleaching over the course of their use in biological environments, which severely compromises the desired theranostic effects. At this point, rylenecarboximide (RI) dyes with ultrahigh photostability hold enormous promise. RI stands for a homologous series of dyes consisting of an aromatic core and carboximide auxochromic groups. They possess high molar extinction coefficients and finely tunable photophysical properties. RIs such as perylenebiscarboxylic acid monoimide (PMI), perylenetetracarboxylic acid diimide (PDI), terrylenetetracarboxylic acid diimide (TDI), and quaterrylene tetracarboxylic acid diimide (QDI) have attracted great scientific attention as colorants, components of organic photovoltaics and organic field-effect tran...Continue Reading

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Citations

Apr 8, 2020·Biomaterials Science·Xiao-Ting GongHao-Li Zhang
Oct 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wenkun HanWenjing Tian
Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhonghua LiuYongwei Huang
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Jan 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuo WangMeng Meng
Mar 11, 2021·Biomaterials·Yuequan WangJin Sun
Nov 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tongxia JinXuhong Qian
Mar 31, 2021·Journal of the American Chemical Society·Pengcai LiuXiao-Ye Wang
Mar 30, 2021·Materials Horizons·Zhen YangXiaoyuan Chen
Jun 24, 2021·ACS Applied Materials & Interfaces·Zhongrui ChenOlivier Siri
May 29, 2020·ACS Applied Materials & Interfaces·Yonghong YangHaifei Zhang

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