From fundamental immunology to development of vaccinology

Médecine sciences : M/S
Jeannine Choppin

Abstract

In the last ten years research in vaccinology has been developed in the world to conceive new vaccine approaches against infections like HIV/AIDS. Jean-Gérard Guillet is a pioneer in the development of new vaccine strategies. From the first results he obtained in the late 80's on the presentation of antigenic peptides to T cells, he axed his work on the study of induction mechanisms of T cell mediated immune responses. The selection of antigenic peptides and the search to enhance antigen immunogenicity led him to elaborate lipopeptides as new vaccine formulae. The efficacy of these preparations was tested in animal models (mouse, macaque) and, thereafter, in humans with clinical trials promoted by the French National Agency for AIDS and viral hepatitis (ANRS). The study of T-cell induced responses in vaccinated volunteers was implemented following the creation of two facilities, an immuno-monitoring platform and the Clinical Investigation Centre Cochin-Pasteur, a structure specialized in vaccinology.

References

Feb 20, 1987·Science·J G GuilletM L Gefter
Mar 1, 1995·European Journal of Immunology·I CouillinJ Choppin
Mar 1, 1994·European Journal of Immunology·F ConnanJ Choppin
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ChoppinJ G Guillet
Dec 12, 2001·Journal of Virology·Valérie Molinier-FrenkelJean-Gérard Guillet
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Frédérique-Anne Le GalHanne Gahéry-Ségard
Jul 12, 2003·The Journal of Biological Chemistry·Valérie Molinier-FrenkelJean-Gérard Guillet
Apr 7, 2005·Nature Medicine·Stefan H E Kaufmann, Andrew J McMichael
Sep 1, 2005·Thérapie·Hanne GaheryJean-Gèrard Guillet
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Judith RacapeJean-Gérard Guillet
Apr 17, 2007·Médecine sciences : M/S·Philippe Sansonetti
Apr 17, 2007·Médecine sciences : M/S·Claude Leclerc
Aug 14, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M E D JarrettI Lindsey
Aug 20, 2009·Acta Crystallographica. Section D, Biological Crystallography·Kenji OkuyamaLuigi Vitagliano

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Citations

May 10, 2008·Médecine sciences : M/S·Camille Legeai, Bertran Auvert
Dec 11, 2019·Ocular Immunology and Inflammation·Chloé CouretMichel Weber

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