From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Zeeba D KabirAnjali M Rajadhyaksha

Abstract

The L-type calcium channels (LTCCs) Cav1.2 and Cav1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx into cells and are critical for normal brain development and plasticity. In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. Separately, CACNA1D has been found to be associated with BD and autism spectrum disorder, as well as cocaine dependence, a comorbid feature associated with psychiatric disorders. Despite growing evidence of a significant link between CACNA1C and CACNA1D and psychiatric disorders, our understanding of the biological mechanisms by which these LTCCs mediate neuropsychiatric-associated endophenotypes, many of which are shared across the different disorders, remains rudimentary. Clinical studies with LTCC blockers testing their efficacy to alleviate symptoms associated with BD, SCZ, and drug dependence have provided mixed results, underscoring the importance of further exploring the neurobiological consequences of dy...Continue Reading

References

Jun 1, 1992·Alcoholism, Clinical and Experimental Research·F FaddaG L Gessa
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·M Perez-ReyesR E Hicks
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·G BartkoE Frecska
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·R L SuddathR J Wyatt
Jan 1, 1992·The American Journal of Psychiatry·E S Garza-TreviñoL E Hollister
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Jan 1, 1991·The American Journal of Hospice & Palliative Care·R E Enck
Jan 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·R M Jacques, S J Cox
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A C AltamuraM Porta
Jun 1, 1990·Clinical Neuropharmacology·G BrunetG Darcourt
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·A H Rezvani, D S Janowsky
Oct 1, 1988·The American Journal of Psychiatry·F J HullettR Ciasca
Jan 15, 1989·Biological Psychiatry·C Höschl, J Kozený
Jul 1, 1986·British Journal of Pharmacology·F BongianniD E Pellegrini-Giampietro
Dec 1, 1987·Journal of Clinical Pharmacology·A J GianniniR H Loiselle
Mar 1, 1988·Psychiatry Research·S B UhrJ G Csernansky
Aug 1, 1986·Psychiatry Research·S L DubovskyJ Murphy
Feb 1, 1987·Archives of General Psychiatry·D PickarP K Narang
Jun 1, 1986·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·L Solomon, P Williamson
Jan 1, 1985·Neuropsychobiology·V Caillard
Dec 1, 1984·The American Journal of Psychiatry·A J GianniniW A Price
May 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·A LenziG B Cassano
Dec 1, 1993·Psychiatry Research·P J PazzagliaL B Marangell
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge

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Citations

Mar 17, 2018·Nature Reviews. Neuroscience·Marc P ForrestPeter Penzes
Nov 2, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marcus SokolowskiDanuta Wasserman
Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caitlin E BurgdorfAnjali M Rajadhyaksha
Mar 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Henry M Colecraft, Rajesh Khanna
May 15, 2020·Experimental Neurobiology·Ting-Wei MiZhao-Qian Teng
Aug 1, 2020·Nutritional Neuroscience·Sian EgertonCatherine Stanton
May 2, 2019·Frontiers in Pharmacology·Antonio VitaMassimo Gennarelli
Jul 25, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
Jun 7, 2020·Journal of Molecular Neuroscience : MN·Yogesh Kumar Dhuriya, Divakar Sharma
Apr 26, 2020·Molecular Psychiatry·Charlotte C BavleyAnjali M Rajadhyaksha
Jul 9, 2020·Molecular Psychiatry·Stephen J HaggartyRoy H Perlis
Jun 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew A Pieper, Jay M Baraban
Sep 8, 2017·Frontiers in Pharmacology·Verónica Giménez De BéjarMiroljub Popović
Sep 27, 2018·Journal of Neuroscience Research·Emma BrännAlkistis Skalkidou
May 20, 2020·Molecular Psychiatry·Chen ZhangMing Li
Dec 20, 2017·International Journal of Molecular Sciences·Zengyan XieKunxian Shu
Jan 5, 2019·European Archives of Psychiatry and Clinical Neuroscience·Alba LubeiroVicente Molina
Jul 5, 2019·Expert Review of Neurotherapeutics·Alfredo B Cuellar-BarbozaSusan L McElroy
Jul 6, 2020·Pflügers Archiv : European journal of physiology·Andrea MarcantoniEmilio Carbone
May 19, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nii A AddyAnjali M Rajadhyaksha
Jun 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah E Swinford-Jackson, R Christopher Pierce
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Akito NakaoNobuaki Takahashi
Jan 26, 2021·Psychiatric Genetics·Delfina JaniriGabriele Sani
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Maria F NotermanEric B Taylor
Jun 9, 2021·Hormones and Behavior·David KabelikLauren A O'Connell
Jan 16, 2019·Molecular Neuropsychiatry·Lucy SykesKerrie L Thomas

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Methods Mentioned

BETA
gene knockout

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