Genome-wide association studies (GWASs) have shown a large number of genetic variants to be associated with complex diseases. The identification of the causal variant within an associated locus can sometimes be difficult because of the linkage disequilibrium between the associated variants and because most GWAS loci contain multiple genes, or no genes at all. Expression quantitative trait locus (eQTL) mapping is a method used to determine the effects of genetic variants on gene expression levels. eQTL mapping studies have enabled the prioritization of genetic variants within GWAS loci, and have shown that trait-associated single nucleotide polymorphisms (SNPs) often function in a tissue- or cell type-specific manner, sometimes having downstream effects on completely different chromosomes. Furthermore, recent RNA-sequencing (RNA-seq) studies have shown that a large repertoire of transcripts is available in cells, which are actively regulated by (trait-associated) variants. Future eQTL mapping studies will focus on broadening the range of available tissues and cell types, in order to determine the key tissues and cell types involved in complex traits. Finally, large meta-analyses will be able to pinpoint the causal variants withi...Continue Reading
Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data
Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches
DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments
Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs
Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals
Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions
Expression quantitative trait loci (eQTLs) in microRNA genes are enriched for schizophrenia and bipolar disorder association signals
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure
From association to prediction: statistical methods for the dissection and selection of complex traits in plants
Multi-omic data integration and analysis using systems genomics approaches: methods and applications in animal production, health and welfare
Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2
Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)
Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation
Susceptibility loci for sporadic brain arteriovenous malformation; a replication study and meta-analysis
Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits
Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize
A trans-acting Variant within the Transcription Factor RIM101 Interacts with Genetic Background to Determine its Regulatory Capacity
Genetic susceptibility variants for lung cancer: replication study and assessment as expression quantitative trait loci
Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3
Genetic architecture underlying the lignin biosynthesis pathway involves noncoding RNAs and transcription factors for growth and wood properties in Populus
Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue
Divergent Effects of PKC (Protein Kinase C) α in the Human and Animal Heart? Therapeutic Implications for PKC Inhibitors in Cardiac Patients
Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease
Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes
Searching for the Genetic Determinants of Peripheral Arterial Disease: A Review of the Literature and Future Directions
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes.
An integrative systems genetics approach reveals potential causal genes and pathways related to obesity
Systems genomics study reveals expression quantitative trait loci, regulator genes and pathways associated with boar taint in pigs
Association Genetics in Populus Reveal the Allelic Interactions of Pto-MIR167a and Its Targets in Wood Formation
Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci
Expression Quantitative Trait Loci in Equine Skeletal Muscle Reveals Heritable Variation in Metabolism and the Training Responsive Transcriptome
The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs
Compensatory trans -regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae
The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects
Genetic variation in transcription factors and photosynthesis light-reaction genes regulates photosynthetic traits
CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification
Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome
Next Generation Sequencing Based Forward Genetic Approaches for Identification and Mapping of Causal Mutations in Crop Plants: A Comprehensive Review
Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.
Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression
Genetic Architecture Underlying the Metabolites of Chlorogenic Acid Biosynthesis in Populus tomentosa.
Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease.
Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.
A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.
B cells: Gene Expression
B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.