From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma

Cancer Metastasis Reviews
Dylan C DeanZhenfeng Duan

Abstract

Although the investigation into biomarkers specific for pulmonary metastasis within osteosarcoma (OS) has recently expanded, their usage within the clinic remains sparse. The current screening protocol after any OS diagnosis includes a chest CT scan; however, metastatic lung nodules frequently go undetected and remain the primary cause of death in OS. Recently, screening technologies such as liquid biopsy and next-generation sequencing have revealed a promising array of biomarkers with predictive and diagnostic value for the pulmonary metastasis associated with OS. These biomarkers draw from genomics, transcriptomics, epigenetics, and metabolomics. When assessed in concert, their utility is most promising as OS is a highly heterogeneous cancer. Accordingly, there has been an expansion of clinical trials not only aimed at further demonstrating the significance of these individual biomarkers but to also reveal which therapies resolve the pulmonary metastasis once detected. This review will focus on the recently discovered and novel metastatic biomarkers within OS, their molecular and cellular mechanisms, the expansion of humanized OS mouse models amenable to their testing, and the associated clinical trials aimed at managing the ...Continue Reading

References

Sep 1, 1989·Clinical & Experimental Metastasis·W J KortT E Stehman
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jan 21, 2004·Nature Reviews. Cancer·Andrew P Feinberg, Benjamin Tycko
Dec 17, 2004·Journal of the National Cancer Institute·Ken Garber
Sep 13, 2005·Cancer·Antonio BriccoliMario Mercuri
Feb 20, 2007·Cancer Research·Emily I ChenBrunhilde Felding-Habermann
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nancy GordonEugenie S Kleinerman
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
May 10, 2008·Pediatric Blood & Cancer·Kevin ChenAykut Uren
Jun 26, 2008·PloS One·Cendrine ArchangeJuan Lucio Iovanna
Sep 9, 2008·Cell·Elaine HolmesJeremy K Nicholson
Sep 20, 2008·BMC Bioinformatics·Andrey A PtitsynDouglas H Thamm
Mar 6, 2009·Nature Reviews. Cancer·Milena S NicolosoGeorge A Calin
Jan 14, 2011·The Journal of International Medical Research·J-A YanW-B Li
Aug 13, 2011·The New England Journal of Medicine·Gregg L Semenza
Aug 16, 2011·Clinical & Experimental Metastasis·Joseph L SottnikDouglas H Thamm
Feb 22, 2012·Cancer Research·Kevin B JonesRami I Aqeilan
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Dec 20, 2012·RNA·William R JeckNorman E Sharpless
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
May 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robert E GoldsbyNeyssa Marina
Jun 4, 2013·Experimental Cell Research·Risa HaradaToshihiro Akisue
Oct 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nicole M A WhiteGeorge M Yousef
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weibo PanZhaoming Ye
Mar 29, 2014·Nature·Steve Perrin
Jun 14, 2014·Advances in Experimental Medicine and Biology·Gangxiong HuangEugenie S Kleinerman
Oct 17, 2014·Nature Reviews. Cancer·Maya KansaraDavid M Thomas
Nov 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongqiang DongXuhui Zhou
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jennifer A PerryKatherine A Janeway
Dec 18, 2014·World Journal of Gastroenterology : WJG·Nidhi SinghAnoop Saraya
Mar 10, 2015·Oncotarget·Zaidoun SalahRami I Aqeilan
Mar 31, 2015·The Journal of Clinical Investigation·Jinchang LuJin Wang
May 15, 2015·International Journal of Endocrinology·Anna WojakowskaMonika Pietrowska

❮ Previous
Next ❯

Citations

May 1, 2020·Frontiers in Oncology·Ben WanDafu Chen
Sep 10, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Juncheng CuiZhenfeng Duan
Nov 13, 2020·Frontiers in Oncology·Melissa Quintero EscobarLjubica Tasic
Mar 23, 2021·Canine Medicine and Genetics·Grace L EdmundsDan G O'Neill
Jun 12, 2021·The British Journal of Radiology·Helcio Mendonça PereiraMarcello Henrique Nogueira-Barbosa
Jul 3, 2021·Cells·Miguel Esperança-MartinsSérgio Dias
Jul 29, 2021·Current Osteoporosis Reports·Jessica Whitburn, Claire M Edwards

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
blood draw
xenograft
biopsies
RNA-Seq
surgical resection

Clinical Trials Mentioned

NCT03108677
NCT02132182
NCT01807052
NCT01190943
NCT01062438
NCT02811523
NCT02484443
NCT02429973
NCT01886105
NCT01650090

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Zhonghua zhong liu za zhi [Chinese journal of oncology]
Jin-gang Song
AJR. American Journal of Roentgenology
P W GooseH L Twigg
Cancer Treatment Reviews
H Handelsman, S K Carter
© 2022 Meta ULC. All rights reserved