From genotypes of immunoglobulin constant heavy G chains (Fcγ) (GM) genes (IGHG) to phenotypes in childhood asthma

International Archives of Allergy and Immunology
Vivi-Anne Oxelius

Abstract

IgE-mediated allergy is associated with immunoglobulin heavy constant G chain (Fcγ) (GM) genes (IGHG) on chromosome 14q32.3. Investigation of the alternative GM allotypes of γ3, γ1 and γ2 chains has disclosed new structural and functional IgG subclasses and B-cell variants, with possible effects on childhood asthma. To investigate different IGHG (GM) gene complexes in a childhood asthma population for allergy parameters. IGHG alleles and correlated allotypic (allelic) IgG subclass levels were analyzed with a sensitive indirect competitive ELISA in 10-year-old children with bronchial asthma. Individual IGHG diplotype-, genotype- and haplotype-related B cells were compared for allelic IgG subclass levels, IgE sensitization, IgE, IgA and IgM levels, and numbers of peripheral blood eosinophils and lymphocytes. The group with homozygous IGHG*bfn/*bfn (B1/B1 cells) demonstrated low IgG1*f levels (p < 0.001) but increased IgG2*n levels (p < 0.001) together with increasd IgE and IGHG2*n gene dose-dependent IgE sensitization (atopic phenotype). The IGHG*bf-n/*bf-n (B2/B2 cells) demonstrated low IgG1*f (p < 0.05) and IgG2*-n (p < 0.001) and the IGHG*ga-n/*ga-n (B4/B4 cells) low IgG1*a (p < 0.001) and IgG2*-n (p < 0.02) together with low ...Continue Reading

References

Jan 1, 1990·International Archives of Allergy and Applied Immunology·V A Oxelius
Jan 1, 1993·Scandinavian Journal of Rheumatology·V A OxeliusA M Carlsson
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius, A M Carlsson
May 1, 1996·International Archives of Allergy and Immunology·V A OxeliusB Löw
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Oct 16, 1999·Scandinavian Journal of Immunology·V A OxeliusK Musil
Sep 14, 2000·Genome Research·L J Palmer, W O Cookson
Sep 29, 2000·European Journal of Immunology·A AthertonM R Clark
Dec 21, 2002·Immunological Reviews·William Cookson
Mar 29, 2005·Nature Medicine·Daocheng ZhuAndrew Saxon
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Carole Ober
Dec 3, 2005·Science·Falk Nimmerjahn, Jeffrey V Ravetch
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Göran JönssonAnders G Sjöholm
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V-A OxeliusB Björkstén
Oct 16, 2007·Respiratory Medicine·Per M GustafssonBengt Kjellman
Jan 24, 2008·Immunologic Research·Vivi-Anne Oxelius
May 27, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vivi-Anne OxeliusLennart Hammarström
Dec 25, 2009·The New England Journal of Medicine·Patrick M A SleimanHakon Hakonarson

❮ Previous
Next ❯

Citations

Nov 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vivi-Anne Oxelius, Janardan P Pandey
Jun 25, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dylan R AddisJames A Mobley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.